Recombinant erythropoietin receptor protein

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United States of America Patent

PATENT NO 5378808
SERIAL NO

08075069

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Abstract

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The invention described encompasses an isolated DNA sequence encoding all or a portion thereof of a cell surface receptor murine and human erythropoietin (hereinafter EPO-R), along with the isolated polypeptide expressed by the DNA sequence (i.e., isolated EPO-R). The invention also encompasses host cells containing the above-described DNA sequence, preferably, host cells which express the polypeptide encoded by the DNA sequence (EPO-R) at a significantly higher level than that produced by normal red blood cell precursors. The invention further encompasses DNA sequences encoding secreted forms of the human EPO-R and polypeptides corresponding thereto. The EPO-receptor in all of the disclosed forms can be used as models for designing drugs or in pharmaceutical compositions for treating anemias.

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Patent Owner(s)

Patent OwnerAddress
GENETICS INSTITUTE INCMASSACHUSETTS MASSACHUSETTS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
D'Andrea, Alan Winchester, MA 15 111
Jones, Simon S Somerville, MA 10 242
Wong, Gordon G Brookline, MA 53 1856

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