Memantine-containing solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof
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United States of America Patent
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Jan 17, 1995
Grant Date -
N/A
app pub date -
Jul 23, 1993
filing date -
Aug 4, 1992
priority date (Note) -
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Abstract
The present invention provides solid pharmaceutical compositions in dosage form containing an active ingredient or principle, preferably memantine, which exhibit an extended two-phase release profile and which are characterized by the presence of both a water-soluble and a water-insoluble salt of casein, preferably sodium and calcium caseinate, in the matrix thereof, in broad proportions and in a total amount between 5 and 98% by weight of the composition, and with a process for the production thereof.
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