Process for the purification of cyclosporin A

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United States of America Patent

PATENT NO 5382655
SERIAL NO

08066857

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Abstract

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A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree. C. to about 115.degree. C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.

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Patent Owner(s)

Patent OwnerAddress
TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAGPALAGI UT NO 13 DEBRECEN 4042

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Balint, Janos Debrecen, HU 11 54
Deak, Gyorgy Debrecen, HU 2 22
Dencs, Judit Veszprem, HU 1 19
Hajdufi, Csaba Debrecen, HU 1 19
Hanak, Laszlo Boldogkoujfalu, HU 1 19
Karacxony, Erno Debrecen, HU 1 19
Karczub, Anita Hajdunanas, HU 1 19
Kelemen, Janos Veszprem, HU 1 19
Keri, Vilmos Debrecen, HU 43 118
Mako, Berta Debrecen, HU 1 19
Marton, Gyula Veszprem, HU 1 19
Melczer, Istvan Debrecen, HU 7 39
Nagy, Edit Debrecen, HU 2 32
Radnai, Ferenc Debrecen, HU 1 19
Strbka, Gyongyi Veszprem, HU 1 19
Szanya, Tibor Veszprem, HU 1 19

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