Active fragments of fibroblast growth factor
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United States of America Patent
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Feb 7, 1995
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app pub date -
Apr 26, 1993
filing date -
Nov 23, 1990
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Abstract
The present invention relates to novel fragments of basic fibroblast growth factor (bFGF). The mitogenic potency of one of these bFGF fragments, identified as HBF-2 is about 25-50 fold less than that of native bFGF but at least 10.sup.3 -10.sup.4 fold more active than that of previously reported synthetic fragments of bFGF. Therefore, the present invention provides the shortest fragment of bFGF that retains substantial biologic activity.
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