C-22 ring stabilized rapamycin derivatives
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United States of America Patent
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Feb 7, 1995
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N/A
app pub date -
Aug 10, 1993
filing date -
Aug 10, 1993
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Abstract
This invention provides C-22 substituted rapamycin derivatives of the following formulas: ##STR1## and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, solid tumors, fungal infections, adult T-cell leukemia/lymphomas and hyperproliferative vascular disorders.
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