Sulfonamide bonded hydrophilic coatings
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United States of America Patent
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Feb 14, 1995
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N/A
app pub date -
Jan 5, 1993
filing date -
Jan 4, 1991
priority date (Note) -
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Abstract
A method of derivatizing a chromatography matrix having a hydrophobic surface involves reacting the hydrophobic surface with a halosulfonating agent to produce a significant amount of halosulfone groups covalently bonded onto the surface. Sulfonamide bonds then are formed between these halosulfone groups and a group of amine functions on a polyaminated polymer to produce a pellicular anion exchange layer covalently bonded to the surface. The resulting layer is stable in the absence of cross-links between the molecules of the polyaminated polymer.
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