Plasmodium falciparum vaccine comprising a recombinant histidine-rich protein-HRP-II
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United States of America Patent
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Feb 28, 1995
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Aug 20, 1993
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Nov 3, 1987
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Abstract
Recombinant histidine-rich protein of Plasmodium falciparum, its preparation and use. It was possible, by screening two different Plasmodium falciparum cDNA gene banks with an antiserum against a 41 kD protein and by cross-hybridization with the insert DNA of a clone obtained therewith, to isolate a gene which codes for a Histidine-Alanine-rich protein (HRP-II). This protein protects aotus monkeys from infection with P. falciparum and is thus a suitable constituent of a malaria vaccine.
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