Method for diagnosing rheumatoid arthritis
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United States of America Patent
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Mar 7, 1995
Grant Date -
N/A
app pub date -
Feb 19, 1993
filing date -
Feb 19, 1993
priority date (Note) -
Expired
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Abstract
A method is described for diagnosing rheumatoid arthritis by providing a recombinant IgM-specific rheumatoid arthritis-associated antigen and detecting antibodies against the antigen in patient sera. Preliminary steps of making a cDNA library from polyadenylated RNA purified from human cells, selecting recombinants that express the antigen, recloning cDNA containing the antigen gene in a high level expression vector, expressing the antigen in transformed cells, and purifying the antigen are also described.
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