Oligonucleotides with inverted polarity
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United States of America Patent
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Mar 21, 1995
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N/A
app pub date -
Jul 30, 1990
filing date -
Oct 23, 1989
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Abstract
Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity, are useful for forming an extended triple helix with a double-helical nucleotide duplex. The inverted polarity also stabilizes the single-strand oligonucleotides to exonuclease degradation.
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