Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same
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United States of America Patent
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Mar 28, 1995
Grant Date -
N/A
app pub date -
Mar 26, 1993
filing date -
Mar 26, 1993
priority date (Note) -
Expired
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Abstract
Organic compounds for diagnostic imaging which contain at least one aryl group which has been derivatized to contain at least one perfluoro-1H,1H-neopentyl moiety are provided. The perfluoro-1H,1H-neopentyl groups produce a single magnetic resonance to insure a maximum signal to noise ratio. One compound disclosed is 2-O-oleoylglycerol 1,3-bis(7'-{3',5'-di[2'',2''-di(trifluoromethyl)3'', 3'',3''-trifluoropropyl]phenyl}heptanoate). In the preferred embodiment, a lipid emulsion is provided as a carrier vehicle to deliver the derivitized analog to a mammalian recipient. Methods to use these compounds in MRI and computerized tomography are provided.
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