Compounds which inhibit complement and/or suppress immune activity
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United States of America Patent
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Mar 28, 1995
Issued Date -
N/A
app pub date -
Dec 21, 1992
filing date -
Apr 15, 1988
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the pharmaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activities, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.
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