2',5'-phosphorothioate oligoadenylates and their covalent conjugates with polylysine
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United States of America Patent
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Apr 11, 1995
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Jul 16, 1992
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Oct 22, 1987
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Abstract
Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide phosphorothioate linkages is of the Sp configuration possess increased antiviral activity and/or metabolic stability.
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