Process of purifying antler-derived bone growth factors

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United States of America Patent

PATENT NO 5408041
SERIAL NO

08180572

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to the development of bone growth factors as therapeutics for the prevention and treatment of pathological conditions involving bone tissue. The present invention provides biologically active proteinaceous factors comprising polypeptides containing the amino acid sequence M-A-G-L-G-D-E-F-G-D, [SEQ ID NO: 1], (X) F E T L F G A/V E D V I/D A L Q F V C G D, [SEQ ID NO: 2], or A-Y-I-P-I-E-T-L-E-G-I/G-E-L-V-D/Q-T-G/L-Q-F, [SEQ ID NO: 3], or biologically active fragments or sequence analogues thereof. Among the biological properties of the proteinaceous materials of the present invention is the capability to promote the growth and/or differentiation of osteoblastic cells.

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Patent Owner(s)

Patent OwnerAddress
RHONE-POULENC RORER PHARMACEUTICALS INC3C43 500 ARCOLA ROAD P O BOX 1200 COLLEGEVILLE PA 19426
OSTEOSA INC2040 BABCOCK ROAD SUITE 201 SAN ANTONIO TX 78229

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arnett, Timothy R San Antonio, TX 1 4
Burgess, Wilson Gaithersburg, VA 39 757
Crumley, Gregg R Philadelphia, PA 4 14
Garrett, Ian R San Antonio, TX 2 17
Gutierrez, Gloria E San Antonio, TX 2 16
Izbicka, Elzbieta San Antonio, TX 22 155
Morse, Clarence C King of Prussia, PA 7 63
Mundy, Gregory R San Antonio, TX 51 1764
Sabatini, Massimo Neuilly-sur-Seine, FR 9 68

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