Polypeptides and DNA coding therefor
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United States of America Patent
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May 2, 1995
Grant Date -
N/A
app pub date -
Jun 16, 1992
filing date -
Dec 22, 1989
priority date (Note) -
Expired
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Abstract
A serine protease inhibitor, similar in some respects to .alpha..sub.1 -antitrypsin (AAT) but having an unglycosylated molecular weight on PAGE of 32.+-.1 kDa, has been discovered. cDNA encoding the active protein has been cloned and sequenced, so the sequence of the protein has been revealed. Recombinant DNA technology enables the natural polypeptide sequence and related proteins to be prepared, for example by expression in E. coli. The inhibitor may prove useful in the treatment of emphysema, arthritis or septic shock.
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