US Patent No: 5,412,104

Number of patents in Portfolio can not be more than 2000

Ester and alkoxy substituted benzopyrans

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Compounds useful as antihypertensive agents and useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Methods of treating a viral infection using compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating hypertension using compounds of Formula 1.0 wherein R is selected from the group consisting of H, halogen and --C(O)OR.sup.6 ; and R.sup.1 is selected from the group consisting of --OR.sup.14, --O(CH.sub.2).sub.a C(H).sub.3-i Z.sub.i and --O(CH.sub.2).sub.h N(R.sup.15).sub.2.

Loading the Abstract Image... loading....

First Claim

See full text

all claims..

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
SCHERING CORPORATIONKENILWORTH, NJ1110

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Afonso, Adriano 10 Woodmere Rd., West Caldwell, NJ 07006 43 457
Gentles, Margaret J Bloomfield, NJ 6 112
Weinstein, Jay Upper Montclair, NJ 24 205

Cited Art Landscape

Patent Info (Count) # Cites Year
 
SCHERING CORPORATION (4)
5,190,956 Certain N-substituted 3-oximino-2,4-dioxoquinolin-2,4-(1H)diones useful for treating viral infections 9 1990
5,179,093 Quinoline-diones 10 1991
5,179,107 Antiviral quinolinone compounds 11 1991
5,175,151 Antiviral compounds and antihypertensive compounds 40 1992
 
Sandoz, Inc. (2)
4,187,309 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof 5 1977
4,190,659 Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters 11 1977
 
Beecham Group p.l.c. (1)
4,363,811 Anti-hypertensive chromanol derivatives 25 1980
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
4,607,039 Quinoline derivatives which are 5-hydroxytryptamine antagonists 6 1983
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (1)
4,963,655 Boron analogs of amino acid/peptide protease inhibitors 65 1988
 
NIPPON SHINYAKU CO., LTD. (1)
4,526,894 Pharmaceutically active 4-hydroxy-3-benzoyl-2-quinolone derivatives 10 1983
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (1)
5,064,756 Microbial susceptibility assay using 7-N-(aminoacyl)-7-amido-4-methylcoumarins 12 1990
 
Syntex (U.S.A.) Inc. (1)
5,250,547 Benzopyran derivatives 13 1991
 
TOYAMA CHEMICAL CO. (1)
4,954,518 4H-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient 38 1988

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
VERTEX PHARMACEUTICALS INCORPORATED (11)
7,495,103 Modulators of ATP-binding cassette transporters 55 2005
8,829,204 Modulators of ATP-binding cassette transporters 0 2007
8,324,242 Modulators of ATP-binding cassette transporters 16 2009
8,101,767 Modulators of ATP-binding cassette transporters 28 2009
8,354,427 Modulators of ATP-binding cassette transporters 15 2009
8,410,274 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 13 2012
8,802,700 Modulators of ATP-Binding Cassette transporters 0 2012
8,629,162 Modulators of ATP-binding cassette transporters 1 2012
8,614,327 Modulators of ATP-binding cassette transporters 2 2012
8,754,224 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 0 2013
8,741,925 Modulators of ATP-binding cassette transporters 0 2013
 
PHARMACIA & UPJOHN COMPANY (5)
5,723,476 4-hydroxycoumarin-3-carboxamides for the treatment of diabetes mellitus 1 1996
6,310,211 8-hydroxy-7-substituted quinolines as anti-viral agents 12 1997
6,252,080 8-hydroxy-7-substituted quinolines as anti-viral agents 1 1999
6,211,376 8-hydroxy-7-substituted quinolines as anti-viral agents 6 1999
6,500,842 8-hydroxy-7-substituted quinolines as anti-viral agents 1 2001
 
KALYPSYS, INC. (3)
8,258,154 Bicyclic heteroaryl inhibitors of PDE4 0 2007
7,745,646 Bicyclic heteroaryl inhibitors of PDE4 5 2007
8,138,205 Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 0 2009
 
MERCK & CO., INC. (2)
6,150,352 Antagonists of gonadotropin releasing hormone 10 1998
6,147,088 Antagonists of gonadotropin releasing hormone 10 1998
 
Agrevo UK Limited (1)
6,034,121 Chromone fungicides 12 1998
 
AVENTIS PHARMACEUTICALS INC. (1)
7,538,233 Coumarins as iNOS inhibitors 1 2004
 
Kalypsys (1)
8,080,563 Bicyclic heteroaryl inhibitors of PDE4 0 2007
 
MERCK FROSST CANADA LTD. (1)
7,348,433 Quinolinones as prostaglandin receptor ligands 0 2002
 
NOVEXEL (1)
5,968,939 Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments 0 1998
 
SCHERING CORPORATION (1)
5,942,522 Antiviral compounds and antihypertensive compounds 1 1997
 
SIGNAL PHARMACEUTICALS, INC. (1)
5,932,618 Anti-viral agents and methods relating to the use thereof 1 1996
 
SSP CO., LTD. (1)
6,028,081 Substituted quinolone derivatives and pharmaceuticals containing the same 27 1998