Ester and alkoxy substituted benzopyrans

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5412104
SERIAL NO

08030186

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds useful as antihypertensive agents and useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Methods of treating a viral infection using compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating hypertension using compounds of Formula 1.0 wherein R is selected from the group consisting of H, halogen and --C(O)OR.sup.6 ; and R.sup.1 is selected from the group consisting of --OR.sup.14, --O(CH.sub.2).sub.a C(H).sub.3-i Z.sub.i and --O(CH.sub.2).sub.h N(R.sup.15).sub.2.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SCHERING CORPORATIONKENILWORTH, NJ125

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Afonso, Adriano West Caldwell, NJ 42 481
Gentles, Margaret J Bloomfield, NJ 6 126
Weinstein, Jay Upper Montclair, NJ 21 239

Cited Art Landscape

Patent Info (Count) # Cites Year
 
SYNTEX (U.S.A.) INC. (1)
* 5250547 Benzopyran derivatives 13 1991
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (1)
* 5064756 Microbial susceptibility assay using 7-N-(aminoacyl)-7-amido-4-methylcoumarins 12 1990
 
TOYAMA CHEMICAL CO. (1)
* 4954518 4H-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient 39 1988
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (1)
* 4963655 Boron analogs of amino acid/peptide protease inhibitors 66 1988
 
SCHERING CORPORATION (4)
* 5190956 Certain N-substituted 3-oximino-2,4-dioxoquinolin-2,4-(1H)diones useful for treating viral infections 13 1990
* 5179093 Quinoline-diones 10 1991
* 5179107 Antiviral quinolinone compounds 13 1991
* 5175151 Antiviral compounds and antihypertensive compounds 42 1992
 
Beecham Group p.l.c. (1)
* 4363811 Anti-hypertensive chromanol derivatives 25 1980
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
* 4607039 Quinoline derivatives which are 5-hydroxytryptamine antagonists 6 1983
 
NIPPON SHINYAKU CO., LTD. (1)
* 4526894 Pharmaceutically active 4-hydroxy-3-benzoyl-2-quinolone derivatives 12 1983
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
SSP CO., LTD. (1)
* 6028081 Substituted quinolone derivatives and pharmaceuticals containing the same 27 1998
 
VERTEX PHARMACEUTICALS INCORPORATED (17)
7495103 Modulators of ATP-binding cassette transporters 85 2005
* 2009/0105,272 Prodrugs of modulators of ABC transporters 70 2006
* 2011/0064,811 Solid forms of N-[2,4-BIS(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 72 2006
8829204 Modulators of ATP-binding cassette transporters 17 2007
* 2008/0071,095 Modulators of ATP-Binding Cassette Transporters 68 2007
8324242 Modulators of ATP-binding cassette transporters 40 2009
8101767 Modulators of ATP-binding cassette transporters 52 2009
8354427 Modulators of ATP-binding cassette transporters 38 2009
* 2010/0184,739 Modulators of ATP-Binding Cassette Transporters 39 2009
8410274 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 36 2012
8802700 Modulators of ATP-Binding Cassette transporters 18 2012
8629162 Modulators of ATP-binding cassette transporters 20 2012
8614327 Modulators of ATP-binding cassette transporters 21 2012
8754224 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 19 2013
8741925 Modulators of ATP-binding cassette transporters 19 2013
9139530 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 6 2014
9090619 Modulators of ATP-binding cassette transporters 8 2014
 
ALCON LABORATORIES, INC. (1)
8258154 Bicyclic heteroaryl inhibitors of PDE4 1 2007
 
MERCK FROSST CANADA LTD. (1)
7348433 Quinolinones as prostaglandin receptor ligands 0 2002
 
Agrevo UK Limited (1)
* 6034121 Chromone fungicides 13 1998
 
NOVEXEL (1)
* 5968939 Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments 0 1998
 
SCHERING CORPORATION (1)
* 5942522 Antiviral compounds and antihypertensive compounds 1 1997
 
SIGNAL PHARMACEUTICALS, INC. (1)
* 5932618 Anti-viral agents and methods relating to the use thereof 1 1996
 
AVENTISUB LLC (2)
7538233 Coumarins as iNOS inhibitors 1 2004
* 2005/0054,681 Coumarins as iNOS inhibitors 1 2004
 
Kalypsys (1)
8080563 Bicyclic heteroaryl inhibitors of PDE4 1 2007
 
MERCK & CO., INC. (2)
* 6150352 Antagonists of gonadotropin releasing hormone 15 1998
* 6147088 Antagonists of gonadotropin releasing hormone 12 1998
 
THOMAS, DAVID J. (1)
* 2008/0027,112 BICYCLIC HETEROARYL INHIBITORS OF PDE4 7 2007
 
KALYPSYS, INC. (4)
7745646 Bicyclic heteroaryl inhibitors of PDE4 6 2007
8138205 Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 1 2009
* 2010/0081,646 BICYCLIC HETEROARYL INHIBITORS OF PDE4 2 2009
9078887 Bicyclic heteroaryl inhibitors of PDE4 0 2012
 
PHARMACIA & UPJOHN COMPANY (5)
* 5723476 4-hydroxycoumarin-3-carboxamides for the treatment of diabetes mellitus 2 1996
6310211 8-hydroxy-7-substituted quinolines as anti-viral agents 12 1997
6252080 8-hydroxy-7-substituted quinolines as anti-viral agents 1 1999
6211376 8-hydroxy-7-substituted quinolines as anti-viral agents 7 1999
6500842 8-hydroxy-7-substituted quinolines as anti-viral agents 2 2001
* Cited By Examiner