US Patent No: 5,412,104

Number of patents in Portfolio can not be more than 2000

Ester and alkoxy substituted benzopyrans

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Abstract

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Compounds useful as antihypertensive agents and useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Methods of treating a viral infection using compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating hypertension using compounds of Formula 1.0 wherein R is selected from the group consisting of H, halogen and --C(O)OR.sup.6 ; and R.sup.1 is selected from the group consisting of --OR.sup.14, --O(CH.sub.2).sub.a C(H).sub.3-i Z.sub.i and --O(CH.sub.2).sub.h N(R.sup.15).sub.2.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SCHERING CORPORATIONKENILWORTH, NJ1110

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Afonso, Adriano 10 Woodmere Rd., West Caldwell, NJ 07006 43 456
Gentles, Margaret J Bloomfield, NJ 6 111
Weinstein, Jay Upper Montclair, NJ 24 204

Cited Art Landscape

Patent Info (Count) # Cites Year
 
SCHERING CORPORATION (4)
5,190,956 Certain N-substituted 3-oximino-2,4-dioxoquinolin-2,4-(1H)diones useful for treating viral infections 8 1990
5,179,093 Quinoline-diones 10 1991
5,179,107 Antiviral quinolinone compounds 11 1991
5,175,151 Antiviral compounds and antihypertensive compounds 40 1992
 
Sandoz, Inc. (2)
4,187,309 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof 5 1977
4,190,659 Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters 11 1977
 
Beecham Group p.l.c. (1)
4,363,811 Anti-hypertensive chromanol derivatives 25 1980
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
4,607,039 Quinoline derivatives which are 5-hydroxytryptamine antagonists 6 1983
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (1)
4,963,655 Boron analogs of amino acid/peptide protease inhibitors 65 1988
 
NIPPON SHINYAKU CO., LTD. (1)
4,526,894 Pharmaceutically active 4-hydroxy-3-benzoyl-2-quinolone derivatives 10 1983
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (1)
5,064,756 Microbial susceptibility assay using 7-N-(aminoacyl)-7-amido-4-methylcoumarins 12 1990
 
Syntex (U.S.A.) Inc. (1)
5,250,547 Benzopyran derivatives 13 1991
 
TOYAMA CHEMICAL CO. (1)
4,954,518 4H-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient 38 1988

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
VERTEX PHARMACEUTICALS INCORPORATED (11)
7,495,103 Modulators of ATP-binding cassette transporters 53 2005
8,829,204 Modulators of ATP-binding cassette transporters 0 2007
8,324,242 Modulators of ATP-binding cassette transporters 15 2009
8,101,767 Modulators of ATP-binding cassette transporters 27 2009
8,354,427 Modulators of ATP-binding cassette transporters 13 2009
8,410,274 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 12 2012
8,802,700 Modulators of ATP-Binding Cassette transporters 0 2012
8,629,162 Modulators of ATP-binding cassette transporters 1 2012
8,614,327 Modulators of ATP-binding cassette transporters 2 2012
8,754,224 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 0 2013
8,741,925 Modulators of ATP-binding cassette transporters 0 2013
 
PHARMACIA & UPJOHN COMPANY (5)
5,723,476 4-hydroxycoumarin-3-carboxamides for the treatment of diabetes mellitus 1 1996
6,310,211 8-hydroxy-7-substituted quinolines as anti-viral agents 12 1997
6,252,080 8-hydroxy-7-substituted quinolines as anti-viral agents 1 1999
6,211,376 8-hydroxy-7-substituted quinolines as anti-viral agents 6 1999
6,500,842 8-hydroxy-7-substituted quinolines as anti-viral agents 1 2001
 
KALYPSYS, INC. (3)
8,258,154 Bicyclic heteroaryl inhibitors of PDE4 0 2007
7,745,646 Bicyclic heteroaryl inhibitors of PDE4 5 2007
8,138,205 Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 0 2009
 
MERCK & CO., INC. (2)
6,150,352 Antagonists of gonadotropin releasing hormone 8 1998
6,147,088 Antagonists of gonadotropin releasing hormone 8 1998
 
Agrevo UK Limited (1)
6,034,121 Chromone fungicides 12 1998
 
AVENTIS PHARMACEUTICALS INC. (1)
7,538,233 Coumarins as iNOS inhibitors 1 2004
 
Kalypsys (1)
8,080,563 Bicyclic heteroaryl inhibitors of PDE4 0 2007
 
MERCK FROSST CANADA LTD. (1)
7,348,433 Quinolinones as prostaglandin receptor ligands 0 2002
 
NOVEXEL (1)
5,968,939 Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments 0 1998
 
SCHERING CORPORATION (1)
5,942,522 Antiviral compounds and antihypertensive compounds 1 1997
 
SIGNAL PHARMACEUTICALS, INC. (1)
5,932,618 Anti-viral agents and methods relating to the use thereof 1 1996
 
SSP CO., LTD. (1)
6,028,081 Substituted quinolone derivatives and pharmaceuticals containing the same 27 1998