Method of preparing vicinal aminoalcohols
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United States of America Patent
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May 2, 1995
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N/A
app pub date -
Feb 1, 1993
filing date -
Feb 4, 1992
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Abstract
The present invention is concerned with the preparation of N-substituted vicinal aminoalcohol derivatives from the corresponding hydroxyl-protected cyanohydrin derivatives by successive partial reduction, transimination using a primary amine, reduction of the resulting imine and optional removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the starting cyanohydrin derivatives. The present invention is also concerned with certain new enantiomerically pure hydroxyl-protected vicinal aminoalcohols.
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