Controlled release ACTH containing microspheres
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United States of America Patent
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May 9, 1995
Issued Date -
N/A
app pub date -
Jun 30, 1994
filing date -
Mar 12, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
ACTH polymeric controlled release systems are described wherein the ACTH retains good biological activity and is released over an extended period of time following administration by injection. In the preferred embodiment, the ACTH polymeric microspheres are made using very cold temperatures to freeze the polymer-ACTH mixtures into polymeric microspheres with very high retention of biological activity and material. Sustained release of biologically active ACTH is achieved when the microspheres are tested in vitro, extending over a period of greater than one day to several months. Altered release can be achieved by inclusion of degradation modifiers, pore forming agents, and stabilizers of the ACTH.
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