Topical containing aminocaproic acid for preventing secondary hemorrhage following hyphema
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United States of America Patent
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May 16, 1995
Issued Date -
N/A
app pub date -
Apr 6, 1994
filing date -
Jul 23, 1992
priority date (Note) -
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Abstract
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of ten human patients treated with the formulation, none have experienced a secondary hemorrhage and none have experienced adverse side effects. The topical gel formulation is prepared by a process which ensures sterility, a pH compatible with conditions in the aqueous humor, and optimum consistency. A permeation enhancer such as proparacaine can be incorporated into the gel during formulation and be used to enhance the transport of aminocaproic acid across the corneal epithelium.
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