Steroid modified oligonucleotides
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United States of America Patent
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May 16, 1995
Issued Date -
N/A
app pub date -
Jul 26, 1993
filing date -
Jun 6, 1989
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
An oligonucleotide conjugated to a steroid the oligonucleotide comprising: ##STR1## wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl and an alkyl (branched) chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms; B is a naturally occurring base, the steroid is bound to the oligonucleotide utilizing the naturally occurring bases through an (-oxycarbonyl-amino)-decylamine-moiety, and NUC is an oligonucleotide.
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