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Abstract

A device for performance of ligand-receptor assay methods for determining the presence of a liquid. The preferred ligand-receptor pair are antigen-antibody pairs. The device has a membrane having the receptor physically bound to its surface. The membrane is disposed at the top of a body member, and is affixed thereto by means for attaching, which is preferably a cap with a funnel depression. A porous means is disposed below the membrane to absorb liquid. Substantially all of the top surface of the membrane is exposed. The receptor site typically occupies only a portion of the top of the membrane, and in a preferred embodiment, a funnel member releasably attaches to the cap, thereby conveying the sample through only that area of the membrane having the receptor site. The device has a piston means disposed inside the body member, and in air-tight seal with the body member. Means to actuate the piston means are disposed outside the body member. The piston means creates a region of reduced pressure to urge the sample through the membrane.

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First Claim