Amplified hybridization assay

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United States of America Patent

PATENT NO 5424188
SERIAL NO

07963923

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Abstract

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A kit for an amplified hybridization assay is described in which a family of signal-generating secondary probes bind to a primary probe that hybridizes to the target sequence of interest. Thus, an enormously amplified signal is generated by the hybridization event. The assay can be used for a variety of laboratory and clinical purposes and is automatable. A hybridization assay kit is also described. The kit is used for the detection of a target nucleotide sequence. One embodiment of the kit includes a plurality of secondary probes, each secondary probe capable of binding to a distinct binding site of the primary probe.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF PRINCETON UNIVERSITYPRINCETON NJ 08544

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Schneider, Robert J New York, NY 32 642
Shenk, Thomas E Princeton, NJ 15 589

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