Nanocrystalline magnetic iron oxide particles-method for preparation and use in medical diagnostics and therapy

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United States of America Patent

PATENT NO 5427767
SERIAL NO

07882130

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Abstract

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The invention relates to nanocrystalline magnetic particles consisting of gnetic iron oxide core of Fe.sub.3 O.sub.4, gamma-Fe.sub.2 O.sub.3 or mixtures thereof and an envelope chemisorbed to said core, the method for preparation of these particles as well as the use thereof in medical diagnostics and/or therapy. The magnetic particles, according to the invention, are characterized by composition of the coating material of natural or synthetic glycosaminoglycans and/or their derivatives with molecular weights of 500 Da to 250,000 Da, if necessary, covalently cross-linked with appropriate cross-linking agents and/or modified by specific additives.

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Patent Owner(s)

  • INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT BERLIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kresse, Mayk Berlin, DE 10 279
Lawaczeck, Rudiger Berlin, DE 4 141
Pfefferer, Detlef Berlin, DE 2 135

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