Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays
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United States of America Patent
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Jul 4, 1995
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app pub date -
Dec 28, 1992
filing date -
Mar 2, 1988
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Abstract
An immortal human cell line stably expressing a multiplicity of cytochrome P450s is provided. Preferably, the cell line is MCL-5, which stably expresses cytochrome P450 IA1, IA2, IIA3, IIIA4, and IIE1, as well as microsomal epoxide hydrolase. The cell line is useful in mutagenicity, toxicity and metabolism studies.
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