Oral pharmaceutical composition containing cyclosporin and process for preparing same
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United States of America Patent
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Jul 4, 1995
Grant Date -
N/A
app pub date -
May 20, 1993
filing date -
Nov 27, 1990
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The invention relates to a pharmaceutical composition for oral administration containing cyclosporin A and/or cyclosporin G as active ingredient, which possess advantageous absorption characteristics, and to a process for preparing this composition. The composition according to the invention comprises 1 part by mass of one or more cyclosporin(s) dissolved in 4 to 50 parts by volume of propylene glycol, 0 to 25 parts by volume of ethanol and 0.0 to 5 parts by mass of a polyoxyethylene/polyoxypropylene block polymer in homogenized state. Based on examinations carried out at 100.degree. C., the stability of solutions prepared according to the invention does not differ from that of the commercially available Sandimmun oral solution.
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