Oligonucleotides having selectably cleavable and/or abasic sites
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United States of America Patent
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Jul 4, 1995
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N/A
app pub date -
Jul 27, 1990
filing date -
Oct 16, 1984
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Abstract
Polynucleotides containing abasic, cleavable sites are provided. These polynucleotides are useful in a variety of biochemical and chemical contexts, particularly in solid phase nucleic acid hybridization assays because a captured probe can be released from the support. The polynucleotides have the structure ##STR1## where R is selected from the group consisting of 2-nitrobenzyl, 4-penten-1-yl, ##STR2## where R', R.sub.i and R.sub.j are as defined herein. One of the preferred embodiments is a polynucleotide where R is ##STR3##
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