Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
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United States of America Patent
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Jul 11, 1995
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N/A
app pub date -
Oct 9, 1990
filing date -
Oct 9, 1990
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Abstract
The disclosure describes a method for incorporating into double stranded DNA and RNA base pairs composed of pairing units that fit the Watson-Crick geometry in that they involve a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six membered ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but with a pattern of hydrogen bonds holding the base pair together different from that found in the AT and GC base pairs (a 'non-standard base pair').
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