Magnetic resonance imaging assisted cryosurgery

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United States of America Patent

PATENT NO 5433717
SERIAL NO

08035455

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Abstract

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Methods and apparatus for magnetic resonance imaging (MRI) assisted cryosurgery. Optimal probe placements and cooling parameters are calculated prior to cryosurgery using MRI data. A MRI compatible cryoprobe and a stereotactic probe positioning device are provided. The resolution of MR images is enhanced by mounting a radio frequency MR coil on the intracorporeal end of a cryoprobe. During cryosurgery the temperature distribution in the frozen region is solved by determining the boundary of the frozen region and solving the heat equation for the known boundary conditions. During cryosurgery the temperature distribution in the unfrozen region is determined by T1 measurements. The process of freezing is controled using information from the solution of the energy equation in the frozen region and temperature measurements in the unfrozen region. After cryosurgery the extent of the tissue damage may be ascertained using phosphorus-31 and/or sodium-23 spectroscopy with a special coil set on the cryosurgical probe.

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Patent Owner(s)

Patent OwnerAddress
REGENTS OF THE UNIVERSITY OF CALIFORNIA THE300 LAKESIDE DRIVE 22ND FLOOR OAKLAND CA 94612 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gilbert, John Berkeley, CA 84 2842
Pease, Grant Oakland, CA 8 793
Roos, Mark San Francisco, CA 8 316
Rubinsky, Boris Albany, CA 114 9708
Wong, Sam Emeryville, CA 7 461

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