Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
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United States of America Patent
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Jul 18, 1995
Issued Date -
N/A
app pub date -
Oct 26, 1993
filing date -
Jun 1, 1992
priority date (Note) -
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Abstract
Oligonucleotide analogs having one or more substitute linkages of the formula 2'/3'--S--CH.sub.2 --CH.dbd.5' or 2'/3'--O--CH.sub.2 --CH.dbd.5' between adjacent nucleomonomers are disclosed. The substitute linkage replace the usual phosphodiester linkage found in unmodified nucleic acids. The oligonucleotide analogs are easy to synthesize, stable in vivo, resistant to endogenous nucleases and are able to hybridize to target nucleic acid sequences in a sequence specific manner.
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