Sustained release suppositories and a process for preparation
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United States of America Patent
Stats
-
Jul 25, 1995
Grant Date -
N/A
app pub date -
Dec 15, 1992
filing date -
Dec 20, 1991
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A sustained release suppository comprising in a usual suppository base a) a water-soluble therapeutically active substance, the average particle size of which is smaller than 20 .mu.m, b) a physiologically acceptable organic substance which is swellable in contact with water, and c) hydrophobic silicium dioxide. The suppository base is usually a fat having a melting range of from 29.degree. to 38.degree. C. As ingredient b) cellulose derivatives such as hydroxypropylmethylcellulose may be used, in a quantity of from 5 to 40% by weight, preferably 9 to 15% by weight. Ingredient c) is preferably used in a quantity of from 3 to 6% by weight. Also a process for manufacturing the suppositories is described.
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