Aminoanthraquinone derivatives to combat multidrug resistance

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United States of America Patent

PATENT NO 5436243
SERIAL NO

08152894

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Potentiating agents inhibit the development of multidrug resistance, reduce drug-resistance in drug-resistant tumors, or sensitize tumors to antineoplastic drugs, thereby potentiating the effect of antineoplastic agents. The potentiating agents are aminoanthraquinones, preferably 1,4-bis(N-substituted) amino anthraquinones, and pharmaceutically acceptable salts thereof.

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Patent Owner(s)

  • DUKE UNIVERSITY;RESEARCH TRIANGLE INSTITUTE;SPHINX PHARMACEUTICALS CORPORATION;PHARMACEUTICALS CORPORATION;RESEARCH TRIANGLE INSTITUTE DUKE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ballas, Lawrence M Apex, NC 1 52
Bell, Robert Durham, NC 85 1333
Carroll, R Ivy Durham, NC 1 52
Fine, Robert L Durham, NC 3 54
Sachs, Clifford W Durham, NC 1 52

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