Electroporation system with voltage control feedback for clinical applications
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United States of America Patent
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Aug 8, 1995
Grant Date -
N/A
app pub date -
Apr 1, 1993
filing date -
Apr 1, 1993
priority date (Note) -
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Abstract
A method and apparatus are provided for introducing macromolecules such as genes and pharmacological compounds into cells of a patient for therapeutic purposes. An apparatus for the therapeutic application of electroporation to a portion of the anatomy of a patient, includes adjustably spaced electrodes for generating an electric field at a preselected location within a body of a patient, a sensor for generating a distance signal proportionate to the space between the electrodes, and an electrical signal generator responsive to the distance signal for applying an electric signal to the electrodes for causing the repeated generation of electric fields of a predetermined amplitude and duration forcing the walls of preselected cells in the body portion to be transiently permeable for permitting the macromolecules to enter the preselected cells.
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