Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
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United States of America Patent
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Aug 8, 1995
Grant Date -
N/A
app pub date -
Feb 22, 1993
filing date -
Feb 22, 1993
priority date (Note) -
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Abstract
In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.
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