Granulated preparations and method of producing the same
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United States of America Patent
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Aug 22, 1995
Issued Date -
N/A
app pub date -
Mar 25, 1994
filing date -
Apr 28, 1990
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Granulated preparations are provided by causing a granular, preferably spherical polyglycerol fatty acid ester having a melting poing of 40.degree.-80.degree. C. together with a powder for fluidized bed formation and heating the resulting fluidized mixture at a temperature in the vicinity of the melting point of the polyglycerol fatty acid ester. The powder may be contain as least one pharmacologically active ingredient. The polyglycerol fatty acid ester shows no crystal polymorphism and does not inactivate the pharmacologically active ingredient. Furthermore, the dissolution and release of the pharmacologically active ingredient can be controlled by varying the HLB of the polyglycerol fatty acid ester.
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