US Patent No: 5,444,041

Number of patents in Portfolio can not be more than 2000

Convertible microemulsion formulations

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Abstract

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There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ATHENA NEUROSCIENCES, INC.SOUTH SAN FRANCISCO, CA17

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Owen, Albert J West Chester, PA 6 232
Sarkahian, Ani B Bryn Mawr, PA 2 149
Yiv, Seang H Wilmington, DE 8 391

Cited Art Landscape

Patent Info (Count) # Cites Year
 
UNIVERSITY OF VIRGINIA (1)
* 5,036,045 Method for increasing growth hormone secretion 16 1988
 
The Regents of the University of California (1)
* 4,692,433 Method and composition for regulating serum calcium levels of mammals 88 1985
 
RICHARDSON-VICKS INC. (2)
* 4,781,914 Sunscreen and moisturizer 18 1985
* 4,720,353 Stable pharmaceutical w/o emulsion composition 66 1987
 
FD MANAGEMENT, INC. (1)
* 4,797,273 Skin moisturizing microemulsions 46 1986
 
NC Development, Inc. (1)
* 5,037,653 Pesticidal chemical formulations 49 1989
 
Chesebrough-Pond's USA Co., Division of Conopco, Inc. (1)
* 4,980,084 Water rinsable petroleum jelly compositions 10 1988
 
FERRIS PHARMACEUTICALS INC. (1)
* 5,064,653 Hydrophilic foam compositions 73 1988
 
CHESEBROUGH-POND'S INC., A CORP. OF NY. (1)
* 4,690,774 Novel translucent water in oil emulsions 20 1985
 
MEIJI MILK PRODUCTS CO., LTD. (1)
* 4,931,210 Process for producing a W/O/W type multiple emulsion for medicines, cosmetics, etc. 19 1988
 
MULLER, BERND W. (1)
* 4,719,239 Pharmaceutical multicomponent systems and method of preparing same 115 1985
 
KOREA FOOD RESEARCH INSTITUTE (1)
* 5,084,289 Method for the inhibition of oxidation of edible oils utilizing a fat soluble anti-oxidant and a water soluble anti-oxdant in a reverse micelle system 29 1990
 
AAIPHARMA SERVICES CORP. (1)
* 5,206,219 Oral compositions of proteinaceous medicaments 198 1991
 
PFIZER INC. (2)
* 4,395,394 Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants 12 1981
* 4,806,350 Vaccine formulation 48 1986
 
Ribi ImmunoChem Research, Inc. (2)
* 4,803,070 Immunological emulsion adjuvants for polysaccharide vaccines 42 1986
* 4,806,352 Immunological lipid emulsion adjuvant 41 1986
 
Societe Nationale Elf Aquitaine (1)
* 4,460,692 Microemulsion of nutrient substances 15 1983
 
Bayer Aktiengesellschaft (1)
* 4,711,902 Medicament formulation 38 1984
 
MEDAPHORE (1)
* 4,914,084 Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body 20 1987
 
KAO CORPORATION (1)
* 5,036,108 Water-in-oil emulsion cosmetic 28 1989
 
GIST-BROCADES N.V. (1)
* 4,481,188 Vaccines 18 1982
 
SYNTHETIC BLOOD CORPORATION (1)
* 4,963,367 Drug delivery compositions and methods 268 1987
 
SMUCKER FRUIT PROCESSING COMPANY (1)
* 5,045,337 Food microemulsion 40 1990
 
AMERICAN CYANAMID COMPANY (1)
* 4,650,677 Method of preparing adjuvanted live attenuated vaccines and adjuvanted live attenuated vaccines thus obtained 10 1984
 
ATHENA NEUROSCIENCES, INC. (1)
* 5,110,606 Non-aqueous microemulsions for drug delivery 36 1990
 
RORER PHARMACEUTICAL CORPORATION (2)
* 5,026,825 Intranasal calcitonin formulations 16 1988
* 5,002,771 Calcitonin suppository formulations 25 1989
 
TROPONWERKE GMBH & CO. KG, A CORP. OF GERMANY (1)
* 4,731,384 Etofenamate formulation 25 1986
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
FIRMENICH SA (1)
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Other [Check patent profile for assignment information] (10)
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* 2005/0163,771 Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals 2 2005
* 2006/0263,397 Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same 0 2006
* 2008/0159,978 Methods for accelerating wound healing by administration of adipokines 3 2008
* 2009/0081,206 METHOD AND PHARMACEUTICAL COMPOSITION FOR INHIBITING PREMATURE RAPTURE OF FETAL MEMBRANES, RIPENING OF UTERINE CERVIX AND PRETERM LABOR IN MAMMALS 13 2008
* 2010/0129,332 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR HEALING WOUNDS 3 2010
* 2010/0310,611 Parenteral and oral formulations of benzimidazoles 0 2010
9,498,485 Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters 0 2015
 
BAR-ILAN UNIVERSITY (2)
8,093,211 Methods and pharmaceutical compositions for healing wounds 0 2009
* 2010/0167,987 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR HEALING WOUNDS 3 2009
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
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NOVARTIS AG (2)
8,575,147 Spontaneously dispersible N-benzoyl staurosporine compositions 0 2007
8,722,664 Spontaneously dispersible N-benzoyl staurosporine compositions 0 2013
 
ASCENT PEDIATRICS, INC. (1)
* 5,672,358 Controlled release aqueous emulsion 12 1995
 
AJINOMOTO CO., INC. (1)
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Societe dʼExploitation de Produits Pour les Industries Chemiques (SEPPIC) (1)
* 6,342,234 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 3 1997
 
ADVANCED MEDICAL OPTICS, INC. (1)
* 2005/0196,370 Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye 37 2005
 
PROTEIN DELIVERY INC. (1)
7,169,889 Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin 1 2000
 
Institut Francais du Petrole (1)
7,605,123 Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof 13 2005
 
DEXCEL LTD (1)
7,732,404 Pro-nanodispersion for the delivery of cyclosporin 0 2006
 
LIPOCINE INC. (11)
6,267,985 Clear oil-containing pharmaceutical compositions 245 1999
6,309,663 Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents 162 1999
6,458,383 Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin 43 2000
6,761,903 Clear oil-containing pharmaceutical compositions containing a therapeutic agent 91 2001
* 2005/0171,193 Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs 13 2005
9,034,858 High-strength testosterone undecanoate compositions 4 2012
8,778,922 Steroidal compositions 5 2012
8,865,695 Steroidal compositions 3 2014
9,358,241 High-strength testosterone undecanoate compositions 0 2014
9,205,057 High-strength testosterone undecanoate compositions 3 2015
9,480,690 High-strength testosterone undecanoate compositions 0 2015
 
UNIVERSITY OF UTAH (1)
* 5,726,154 Stabilization and oral delivery of calcitonin 9 1996
 
CIMA LABS INC. (2)
6,280,770 Microemulsions as solid dosage forms for oral administration 26 1999
6,692,771 Emulsions as solid dosage forms for oral administration 24 2001
 
Heal0r, Ltd. (1)
8,349,793 Method for treatment of inflammatory disease and disorder 0 2011
 
SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (4)
6,274,149 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 4 1995
* 6,117,432 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 20 1997
* 6,251,407 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 4 1997
6,689,370 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 0 2000
 
ARCHIMEDES DEVELOPMENT LIMITED (1)
* 6,228,396 Colonic drug delivery composition 12 1997
 
Sanwa Kagaku Kenkyusho Co., Ltd. (1)
* 5,733,877 Pharmaceutical composition containing biologically active peptide or protein 13 1995
 
HOFFMANN-LA ROCHE INC. (1)
* 6,008,228 Pharmaceutical compositions containing proteinase inhibitors 12 1996
 
NOVO NORDISK A/S (16)
8,119,159 Solid oral dosage form containing an enhancer 21 2006
* 2007/0196,464 Solid oral dosage form containing an enhancer 20 2006
8,323,689 Solid oral dosage form containing an enhancer 13 2008
8,999,383 Compositions of GnRH related compounds and processes of preparation 1 2009
* 2009/0280,170 Compositions of GnRH related compounds and processes of preparation 10 2009
8,883,201 Solid oral dosage form containing an enhancer 7 2009
8,053,429 Solid oral dosage form containing an enhancer 24 2009
* 2010/0215,743 Composition and drug delivery of bisphosphonates 34 2010
8,883,203 Solid oral dosage form containing an enhancer 7 2010
8,323,690 Solid oral dosage form containing an enhancer 13 2010
* 2010/0209,499 Solid Oral Dosage Form Containing an Enhancer 4 2010
* 2011/0182,985 Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof 8 2011
9,089,484 Pharmaceutical compositions of selective factor Xa inhibitors for oral administration 0 2011
* 2011/0236,474 Pharmaceutical Compositions of Selective Factor Xa Inhibitors for Oral Administration 2 2011
8,802,114 Pharmaceutical compositions of iron for oral administration 0 2012
8,828,431 Solid oral dosage form containing an enhancer 8 2012
 
BIOCON LIMITED (39)
* 6,191,105 Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin 58 1997
6,858,580 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 41 2001
6,835,802 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 15 2001
6,828,297 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 14 2001
6,828,305 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2001
6,713,452 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 11 2001
* 2003/0228,275 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0060,606 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0027,995 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0004,304 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 4 2001
6,913,903 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 5 2001
7,060,675 Methods of treating diabetes mellitus 11 2002
6,867,183 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 19 2002
7,713,932 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7,608,584 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7,196,059 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 3 2003
7,166,571 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 2 2003
* 2003/0229,009 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 0 2003
7,312,192 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 0 2003
* 2003/0228,652 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 2 2003
7,601,688 Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus 1 2003
7,030,084 Drug-oligomer conjugates with polyethylene glycol components 25 2004
* 2004/0223,948 Drug-oligomer conjugates with polyethylene glycol components 2 2004
7,084,121 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2004
7,084,114 Mixtures of insulin drug-oligomer comprising polyalkylene glycol 9 2004
7,611,864 Proinsulin polypeptide-oligomer conjugates 0 2004
* 2005/0080,001 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 3 2004
7,875,700 Cation complexes of insulin compound conjugates, formulation and uses thereof 5 2005
7,872,095 Insulin-oligomer conjugates, formulations and uses thereof 4 2005
* 2006/0019,873 Cation complexes of insulin compound conjugates, formulations and uses thereof 2 2005
7,423,014 Insulin conjugates for treating diabetes mellitus 11 2005
* 2006/0100,137 Methods of treating diabetes mellitus 0 2005
7,470,663 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2006
7,381,702 Methods of treating diabetes mellitus 0 2006
9,241,908 Orally administrable solid pharmaceutical composition and a process thereof 0 2008
8,563,685 Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof 0 2009
8,030,269 Calcitonin drug-oligomer conjugates, and uses thereof 0 2009
9,102,758 Insulin-oligomer conjugates, formulations and uses thereof 0 2011
9,101,596 Cation complexes of insulin compound conjugates, formulations and uses thereof 0 2011
 
LG CHEM, LTD. (1)
* 2007/0093,610 Method for preparing styrene and maleimide copolymer using super critical fluid 1 2004
 
HealOr Ltd. (8)
* 2006/0258,562 Methods and pharmaceutical compositions for healing wounds 11 2006
7,638,484 Methods for accelerating wound healing by administration of adipokines 5 2006
* 2006/0177,418 Methods for accelerating wound healing by administration of adipokines 4 2006
8,367,606 Method and compositions for prevention and treatment of diabetic and aged skin 4 2006
* 2011/0021,422 METHOD AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF DIABETIC AND AGED SKIN 5 2006
* 2010/0310,542 Pharmaceutical Compositions for treating wouds and related methods 3 2008
* 2010/0215,634 VISFATIN THERAPEUTIC AGENTS FOR THE TREATMENT OF ACNE AND OTHER CONDITIONS 6 2010
8,507,431 Methods for accelerating wound healing by administration of a preadipocyte modulator or an adipocyte modulator 0 2011
 
SEMBIOSYS GENETICS INC. (2)
* 7,585,645 Thioredoxin and thioredoxin reductase containing oil body based products 1 2001
* 2002/0037,303 Thioredoxin and thioredoxin reductase containing oil body based products 6 2001
 
BEIERSDORF AG (1)
* 2005/0124,705 Cosmetic or pharmaceutical, low-viscosity oil-in-water emulsions containing phospholipids 7 2004
 
NATURA, INC. (1)
* 5,766,636 Edible, low calorie compositions of a carrier and an active ingredient and methods for preparation thereof 6 1995
 
NOF CORPORATION (1)
* 5,814,321 Oil adjuvant vaccine and method for preparing same 8 1996
 
HEWLETT-PACKARD COMPANY (1)
* 6,024,786 Stable compositions of nano-particulate unmodified pigments and insoluble colorants in aqueous microemulsions, and principle of stability and methods of formation thereof 36 1997
 
The Regents of the University of California (1)
* 2007/0021,378 Heparin compositions and selectin inhibition 17 2006
 
L'OREAL (2)
* 6,506,391 Cosmetic or dermatological composition in the form of a dispersion of an oily phase and an aqueous phase, stabilized with cubic gel particles 27 1999
* 2002/0187,174 Cosmetic or dermatological composition in the form of a dispersion of an oily phase and an aqueos phase, stabilized with cubic gel particles 1 2002
 
SANGUIBIOTECH GMBH (1)
* 2005/0232,953 Microemulsions having a binary phase differentiability and active substance differentiability, the production thereof and their use, particularly for the topical supply of oxygen 9 2004
 
PLIVA, INC. (1)
7,452,552 Pharmaceutical compositions for lipophilic drugs 0 2007
 
Vesifact AG (3)
7,081,253 Use of nanodispersions in pharmaceutical end formulations 1 1999
7,871,642 Use of nanodispersions in pharmaceutical end formulations 0 2006
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MERRION RESEARCH III LIMITED (1)
* 2007/0148,228 Solid oral dosage form containing an enhancer 28 2006
 
SHISEIDO COMPANY, LTD. (1)
* 2005/0003,976 Sympathetic nerve-stimulating fragrant compositions 3 2004
 
ENCINAL PHARMACEUTICAL INVESTMENTS, LLC (5)
* 6,174,547 Dosage form comprising liquid formulation 43 1999
7,147,867 Dosage form comprising liquid formulation 2 2000
* 2001/0001,280 Dosage form comprising liquid formulation 5 2000
7,803,401 Dosage form comprising liquid formulation 0 2006
* 2007/0048,368 Dosage form comprising liquid formulation 1 2006
 
GS DEVELOPMENT AB (1)
* 6,660,278 Controlled release composition 13 1999
 
SUMITOMO DAINIPPON PHARMA CO., LTD. (2)
* 8,178,102 Emulsified composition for dilution and cancer vaccine composition 0 2006
* 2009/0136,572 EMULSIFIED COMPOSITION FOR DILUTION AND CANCER VACCINE COMPOSITION 0 2006
 
Hahntech International Limited (1)
* 6,582,749 Low fat edible emulsions 6 2001
 
WATSON LABORATORIES, INC. (7)
* 5,858,401 Pharmaceutical composition for cyclosporines 85 1997
7,070,802 Pharmaceutical compositions for lipophilic drugs 11 2001
7,988,995 Pharmaceutical compositions for lipophilic drugs 7 2002
8,119,157 Pharmaceutical compositions for lipophilic drugs 0 2006
* 2006/0188,561 Pharmaceutical compositions for lipophilic drugs 1 2006
7,799,340 Pharmaceutical compositions for lipophilic drugs 7 2007
* 2007/0259,810 PHARMACEUTICAL COMPOSITIONS FOR LIPOPHILIC DRUGS 0 2007
 
KAO CORPORATION (1)
* 5,693,258 Method for improving foaming properties and foaming composition 36 1994
 
COGNIS DEUTSCHLAND GMBH & CO. KG (1)
* 5,817,254 Free-flowing emulsion concentrate 7 1996
 
ABBOTT LABORATORIES (5)
* 2005/0014,287 Stable calibrators or controls for measuring human natriuretic peptides 8 2003
7,291,501 Stable compositions for measuring human natriuretic peptides 1 2003
* 7,351,586 Method of making stable calibrators or controls for measuring human natriuretic peptides 4 2005
7,674,623 Method of stabilizing human natriuretic peptides 0 2007
* 2008/0248,579 Method of stabilizing human natriuretic peptides 0 2007
 
APOLLO LIFE SCIENCES LIMITED (1)
* 2007/0243,132 Transdermal delivery of pharmaceutical agents 37 2006
 
MERIAL, INC. (2)
* 9,107,859 Vaccine formulations comprising saponin-containing adjuvants 0 2010
* 2011/0129,494 Vaccine Formulations Comprising Saponin-containing Adjuvants 1 2010
 
ATHENA NEUROSCIENCES, INC. (6)
* 5,646,109 Convertible microemulsion formulations 37 1995
* 5,633,226 Convertible microemulsion formulations 41 1995
* 5,688,761 Convertible microemulsion formulations 39 1995
6,245,349 Drug delivery compositions suitable for intravenous injection 35 1996
6,241,969 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery 149 1998
8,466,134 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery 0 1999
 
COLUMBIA LABORATORIES, INC. (4)
7,153,845 Bioadhesive progressive hydration tablets 10 2003
* 2004/0001,887 Bioadhesive progressive hydration tablets 2 2003
8,765,177 Bioadhesive progressive hydration tablets 0 2006
* 2007/0031,491 Bioadhesive progressive hydration tablets 12 2006
 
UNIVERSITY OF HOUSTON (3)
* 9,259,390 Parenteral and oral formulations of benzimidazoles 0 2008
* 2009/0048,322 Parenteral and oral formulations of benzimidazoles 3 2008
* 9,259,391 Parenteral and oral formulations of benzimidazoles 0 2010
* Cited By Examiner