Convertible microemulsion formulations

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5444041
SERIAL NO

07885202

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ATHENA NEUROSCIENCES, INC.PICKERINGTON, OH12

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Owen, Albert J West Chester, PA 6 232
Sarkahian, Ani B Bryn Mawr, PA 2 149
Yiv, Seang H Wilmington, DE 8 400

Cited Art Landscape

Patent Info (Count) # Cites Year
 
UNIVERSITY OF VIRGINIA (1)
* 5036045 Method for increasing growth hormone secretion 17 1988
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
* 4692433 Method and composition for regulating serum calcium levels of mammals 88 1985
 
RICHARDSON-VICKS INC. (2)
* 4781914 Sunscreen and moisturizer 18 1985
* 4720353 Stable pharmaceutical w/o emulsion composition 68 1987
 
FD MANAGEMENT, INC. (1)
* 4797273 Skin moisturizing microemulsions 46 1986
 
NC Development, Inc. (1)
* 5037653 Pesticidal chemical formulations 50 1989
 
Chesebrough-Pond's USA Co., Division of Conopco, Inc. (1)
* 4980084 Water rinsable petroleum jelly compositions 10 1988
 
FERRIS PHARMACEUTICALS INC. (1)
* 5064653 Hydrophilic foam compositions 74 1988
 
CHESEBROUGH-POND'S INC., A CORP. OF NY. (1)
* 4690774 Novel translucent water in oil emulsions 20 1985
 
MEIJI MILK PRODUCTS CO., LTD (1)
* 4931210 Process for producing a W/O/W type multiple emulsion for medicines, cosmetics, etc. 20 1988
 
KOREA FOOD RESEARCH INSTITUTE (1)
* 5084289 Method for the inhibition of oxidation of edible oils utilizing a fat soluble anti-oxidant and a water soluble anti-oxdant in a reverse micelle system 34 1990
 
AAIPHARMA SERVICES CORP. (1)
* 5206219 Oral compositions of proteinaceous medicaments 216 1991
 
PFIZER INC. (2)
* 4395394 Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants 12 1981
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RIBI IMMUNOCHEM RESEARCH, INC. (2)
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* 4806352 Immunological lipid emulsion adjuvant 41 1986
 
Societe Nationale Elf Aquitaine (Production) (1)
* 4460692 Microemulsion of nutrient substances 15 1983
 
BAYER AKTIENGESELLSCHAFT (1)
* 4711902 Medicament formulation 39 1984
 
MEDAPHORE (1)
* 4914084 Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body 20 1987
 
KOLLN, CLAUS-JURGEN (1)
* 4719239 Pharmaceutical multicomponent systems and method of preparing same 115 1985
 
ATHENA NEUROSCIENCES, INC. (1)
* 5110606 Non-aqueous microemulsions for drug delivery 37 1990
 
KAO CORPORATION (1)
* 5036108 Water-in-oil emulsion cosmetic 28 1989
 
Gist-Brocades N.V. (1)
* 4481188 Vaccines 18 1982
 
SYNTHETIC BLOOD CORPORATION (1)
* 4963367 Drug delivery compositions and methods 276 1987
 
SMUCKER FRUIT PROCESSING COMPANY (1)
* 5045337 Food microemulsion 40 1990
 
American Cyanamid Company (1)
* 4650677 Method of preparing adjuvanted live attenuated vaccines and adjuvanted live attenuated vaccines thus obtained 10 1984
 
RORER PHARMACEUTICAL CORPORATION (2)
* 5026825 Intranasal calcitonin formulations 16 1988
* 5002771 Calcitonin suppository formulations 25 1989
 
TROPONWERKE GMBH & CO. KG, A CORP. OF GERMANY (1)
* 4731384 Etofenamate formulation 27 1986
* Cited By Examiner

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Patent Info (Count) # Cites Year
 
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* 2003/0077,306 Emulsions as solid dosage forms for oral administration 12 2002
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* 2008/0139,392 Linker-Based Lecithin Microemulsion Delivery Vehicles 15 2006
* 2008/0159,978 Methods for accelerating wound healing by administration of adipokines 3 2008
* 2009/0081,206 METHOD AND PHARMACEUTICAL COMPOSITION FOR INHIBITING PREMATURE RAPTURE OF FETAL MEMBRANES, RIPENING OF UTERINE CERVIX AND PRETERM LABOR IN MAMMALS 13 2008
* 2010/0129,332 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR HEALING WOUNDS 3 2010
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NOVARTIS AG (2)
8575147 Spontaneously dispersible N-benzoyl staurosporine compositions 0 2007
8722664 Spontaneously dispersible N-benzoyl staurosporine compositions 0 2013
 
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PROTEIN DELIVERY INC. (1)
7169889 Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin 1 2000
 
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6267985 Clear oil-containing pharmaceutical compositions 262 1999
6309663 Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents 176 1999
6458383 Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin 46 2000
6761903 Clear oil-containing pharmaceutical compositions containing a therapeutic agent 103 2001
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9034858 High-strength testosterone undecanoate compositions 4 2012
8778922 Steroidal compositions 5 2012
8865695 Steroidal compositions 3 2014
9358241 High-strength testosterone undecanoate compositions 0 2014
9205057 High-strength testosterone undecanoate compositions 3 2015
9498485 Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters 0 2015
9480690 High-strength testosterone undecanoate compositions 0 2015
 
UNIVERSITY OF UTAH (1)
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SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (4)
6274149 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 4 1995
* 6117432 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 21 1997
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6689370 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 0 2000
 
SANWA KAGAKU KENKYUSHO CO., LTD. (1)
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L'OREAL (2)
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7081253 Use of nanodispersions in pharmaceutical end formulations 1 1999
7871642 Use of nanodispersions in pharmaceutical end formulations 1 2006
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SHISEIDO COMPANY, LTD. (1)
* 2005/0003,976 Sympathetic nerve-stimulating fragrant compositions 3 2004
 
SUMITOMO DAINIPPON PHARMA CO., LTD. (2)
* 8178102 Emulsified composition for dilution and cancer vaccine composition 0 2006
* 2009/0136,572 EMULSIFIED COMPOSITION FOR DILUTION AND CANCER VACCINE COMPOSITION 0 2006
 
ABBOTT LABORATORIES (3)
* 7351586 Method of making stable calibrators or controls for measuring human natriuretic peptides 4 2005
7674623 Method of stabilizing human natriuretic peptides 0 2007
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MERIAL, INC. (2)
* 9107859 Vaccine formulations comprising saponin-containing adjuvants 0 2010
* 2011/0129,494 Vaccine Formulations Comprising Saponin-containing Adjuvants 2 2010
 
UNIVERSITY OF HOUSTON SYSTEM (3)
* 9259390 Parenteral and oral formulations of benzimidazoles 0 2008
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* 9259391 Parenteral and oral formulations of benzimidazoles 0 2010
 
FIRMENICH SA (1)
* 6582682 Oral care compositions comprising stabilized chlorine dioxide 17 2002
 
BAR-ILAN UNIVERSITY (2)
8093211 Methods and pharmaceutical compositions for healing wounds 2 2009
* 2010/0167,987 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR HEALING WOUNDS 3 2009
 
ASCENT PEDIATRICS, INC. (1)
* 5672358 Controlled release aqueous emulsion 14 1995
 
AJINOMOTO CO., INC. (1)
* 5854199 Cleaning compositions containing acylated dipeptides and acylated amino acids 3 1997
 
ADVANCED MEDICAL OPTICS, INC. (1)
* 2005/0196,370 Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye 45 2005
 
IFP (1)
7605123 Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof 15 2005
 
DEXCEL LTD. (1)
7732404 Pro-nanodispersion for the delivery of cyclosporin 0 2006
 
Heal0r, Ltd. (1)
8349793 Method for treatment of inflammatory disease and disorder 0 2011
 
CIMA LABS INC. (2)
6280770 Microemulsions as solid dosage forms for oral administration 30 1999
6692771 Emulsions as solid dosage forms for oral administration 24 2001
 
Archimedes Development Ltd. (1)
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BIOCON LIMITED (39)
* 6191105 Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin 59 1997
6858580 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 44 2001
6835802 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 16 2001
6828297 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 15 2001
6828305 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2001
6713452 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 11 2001
* 2003/0228,275 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0060,606 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0027,995 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0004,304 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 4 2001
6913903 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 5 2001
7060675 Methods of treating diabetes mellitus 13 2002
6867183 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 20 2002
7713932 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7608584 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7196059 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 3 2003
7166571 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 2 2003
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7312192 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 0 2003
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7601688 Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus 1 2003
7030084 Drug-oligomer conjugates with polyethylene glycol components 35 2004
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7084121 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2004
7084114 Mixtures of insulin drug-oligomer comprising polyalkylene glycol 10 2004
7611864 Proinsulin polypeptide-oligomer conjugates 0 2004
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7875700 Cation complexes of insulin compound conjugates, formulation and uses thereof 5 2005
7872095 Insulin-oligomer conjugates, formulations and uses thereof 4 2005
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7423014 Insulin conjugates for treating diabetes mellitus 12 2005
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7470663 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2006
7381702 Methods of treating diabetes mellitus 0 2006
9241908 Orally administrable solid pharmaceutical composition and a process thereof 0 2008
8563685 Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof 0 2009
8030269 Calcitonin drug-oligomer conjugates, and uses thereof 0 2009
9102758 Insulin-oligomer conjugates, formulations and uses thereof 0 2011
9101596 Cation complexes of insulin compound conjugates, formulations and uses thereof 0 2011
 
NOVO NORDISK A/S (17)
8119159 Solid oral dosage form containing an enhancer 44 2006
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8999383 Compositions of GnRH related compounds and processes of preparation 1 2009
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8883201 Solid oral dosage form containing an enhancer 30 2009
8053429 Solid oral dosage form containing an enhancer 45 2009
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8883203 Solid oral dosage form containing an enhancer 30 2010
8323690 Solid oral dosage form containing an enhancer 36 2010
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8802114 Pharmaceutical compositions of iron for oral administration 0 2012
8828431 Solid oral dosage form containing an enhancer 31 2012
 
LG CHEM, LTD. (1)
* 2007/0093,610 Method for preparing styrene and maleimide copolymer using super critical fluid 1 2004
 
SEMBIOSYS GENETICS INC. (2)
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7638484 Methods for accelerating wound healing by administration of adipokines 5 2006
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8367606 Method and compositions for prevention and treatment of diabetic and aged skin 4 2006
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8507431 Methods for accelerating wound healing by administration of a preadipocyte modulator or an adipocyte modulator 0 2011
 
Centre National de la Recherche Scientifiquue (C.N.R.S.) (1)
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NOF CORPORATION (1)
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7153845 Bioadhesive progressive hydration tablets 10 2003
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MERRION RESEARCH III LIMITED (1)
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ENCINAL PHARMACEUTICAL INVESTMENTS, LLC (5)
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7147867 Dosage form comprising liquid formulation 4 2000
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7803401 Dosage form comprising liquid formulation 0 2006
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MICELLE PRODUCTS, INC. (1)
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GS DEVELOPMENT AB (1)
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Watson Laboratories, Inc. (7)
* 5858401 Pharmaceutical composition for cyclosporines 92 1997
7070802 Pharmaceutical compositions for lipophilic drugs 11 2001
7988995 Pharmaceutical compositions for lipophilic drugs 7 2002
8119157 Pharmaceutical compositions for lipophilic drugs 0 2006
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7799340 Pharmaceutical compositions for lipophilic drugs 7 2007
* 2007/0259,810 PHARMACEUTICAL COMPOSITIONS FOR LIPOPHILIC DRUGS 0 2007
 
Hahntech International Limited (1)
* 6582749 Low fat edible emulsions 7 2001
 
KAO CORPORATION (1)
* 5693258 Method for improving foaming properties and foaming composition 46 1994
 
ATHENA NEUROSCIENCES, INC. (6)
* 5646109 Convertible microemulsion formulations 37 1995
* 5633226 Convertible microemulsion formulations 41 1995
* 5688761 Convertible microemulsion formulations 39 1995
6245349 Drug delivery compositions suitable for intravenous injection 39 1996
6241969 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery 151 1998
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* Cited By Examiner