US Patent No: 5,444,041

Number of patents in Portfolio can not be more than 2000

Convertible microemulsion formulations

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Abstract

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There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ATHENA NEUROSCIENCES, INC.SOUTH SAN FRANCISCO, CA58

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Owen, Albert J West Chester, PA 6 181
Sarkahian, Ani B Bryn Mawr, PA 2 122
Yiv, Seang H Wilmington, DE 8 317

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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Richardson-Vicks Inc. (2)
4,781,914 Sunscreen and moisturizer 18 1985
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Rorer Pharmaceutical Corporation (2)
5,026,825 Intranasal calcitonin formulations 16 1988
5,002,771 Calcitonin suppository formulations 25 1989
 
AAIPHARMA SERVICES CORP. (1)
5,206,219 Oral compositions of proteinaceous medicaments 139 1991
 
American Cyanamid Company (1)
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ATHENA NEUROSCIENCES, INC. (1)
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4,183,918 Detoxifying-medicinal emulsions 15 1978
 
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4,797,273 Skin moisturizing microemulsions 46 1986
 
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GIST-BROCADES N.V. (1)
4,481,188 Vaccines 14 1982
 
KAO CORPORATION (1)
5,036,108 Water-in-oil emulsion cosmetic 28 1989
 
KOREA FOOD RESEARCH INSTITUTE (1)
5,084,289 Method for the inhibition of oxidation of edible oils utilizing a fat soluble anti-oxidant and a water soluble anti-oxdant in a reverse micelle system 26 1990
 
MEDAPHORE (1)
4,914,084 Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body 20 1987
 
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MULLER, BERND W. (1)
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NC Development, Inc. (1)
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SMUCKER FRUIT PROCESSING COMPANY (1)
5,045,337 Food microemulsion 35 1990
 
Societe Nationale Elf Aquitaine (1)
4,460,692 Microemulsion of nutrient substances 14 1983
 
SYNTHETIC BLOOD CORPORATION (1)
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
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4,731,384 Etofenamate formulation 18 1986
 
UNIVERSITY OF VIRGINIA (1)
5,036,045 Method for increasing growth hormone secretion 15 1988
 
Other [Check patent profile for assignment information] (1)
4,241,051 Calcitonin 14 1978

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
BIOCON LIMITED (26)
6,191,105 Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin 52 1997
6,858,580 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 27 2001
6,835,802 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 10 2001
6,828,297 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 10 2001
6,828,305 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2001
6,713,452 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 11 2001
6,913,903 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 4 2001
7,060,675 Methods of treating diabetes mellitus 7 2002
6,867,183 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 11 2002
7,713,932 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7,608,584 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7,196,059 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 3 2003
7,166,571 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 2 2003
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7,601,688 Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus 1 2003
7,030,084 Drug-oligomer conjugates with polyethylene glycol components 10 2004
7,084,121 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2004
7,084,114 Mixtures of insulin drug-oligomer comprising polyalkylene glycol 8 2004
7,611,864 Proinsulin polypeptide-oligomer conjugates 0 2004
7,875,700 Cation complexes of insulin compound conjugates, formulation and uses thereof 1 2005
7,872,095 Insulin-oligomer conjugates, formulations and uses thereof 0 2005
7,423,014 Insulin conjugates for treating diabetes mellitus 3 2005
7,470,663 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2006
7,381,702 Methods of treating diabetes mellitus 0 2006
8,563,685 Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof 0 2009
8,030,269 Calcitonin drug-oligomer conjugates, and uses thereof 0 2009
 
ATHENA NEUROSCIENCES, INC. (6)
5,646,109 Convertible microemulsion formulations 26 1995
5,633,226 Convertible microemulsion formulations 28 1995
5,688,761 Convertible microemulsion formulations 28 1995
6,245,349 Drug delivery compositions suitable for intravenous injection 31 1996
6,241,969 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery 133 1998
8,466,134 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery 0 1999
 
MERRION RESEARCH III LIMITED (6)
8,119,159 Solid oral dosage form containing an enhancer 4 2006
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8,323,690 Solid oral dosage form containing an enhancer 2 2010
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8,828,431 Solid oral dosage form containing an enhancer 0 2012
 
LIPOCINE INC. (5)
6,267,985 Clear oil-containing pharmaceutical compositions 170 1999
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6,458,383 Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin 33 2000
6,761,903 Clear oil-containing pharmaceutical compositions containing a therapeutic agent 44 2001
8,778,922 Steroidal compositions 0 2012
 
WATSON LABORATORIES, INC. (5)
5,858,401 Pharmaceutical composition for cyclosporines 65 1997
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7,988,995 Pharmaceutical compositions for lipophilic drugs 5 2002
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SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (4)
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7,351,586 Method of making stable calibrators or controls for measuring human natriuretic peptides 4 2005
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ENCINAL PHARMACEUTICAL INVESTMENTS, LLC (3)
6,174,547 Dosage form comprising liquid formulation 30 1999
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HEALOR LTD. (3)
7,638,484 Methods for accelerating wound healing by administration of adipokines 4 2006
8,367,606 Method and compositions for prevention and treatment of diabetic and aged skin 1 2006
8,507,431 Methods for accelerating wound healing by administration of a preadipocyte modulator or an adipocyte modulator 0 2011
 
CIMA LABS INC. (2)
6,280,770 Microemulsions as solid dosage forms for oral administration 22 1999
6,692,771 Emulsions as solid dosage forms for oral administration 18 2001
 
COLUMBIA LABORATORIES, INC. (2)
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8,765,177 Bioadhesive progressive hydration tablets 0 2006
 
NOVARTIS AG (2)
8,575,147 Spontaneously dispersible N-benzoyl staurosporine compositions 0 2007
8,722,664 Spontaneously dispersible N-benzoyl staurosporine compositions 0 2013
 
VESIFACT AG (2)
7,081,253 Use of nanodispersions in pharmaceutical end formulations 1 1999
7,871,642 Use of nanodispersions in pharmaceutical end formulations 0 2006
 
AJINOMOTO CO., INC. (1)
5,854,199 Cleaning compositions containing acylated dipeptides and acylated amino acids 2 1997
 
ARCHIMEDES DEVELOPMENT LIMITED (1)
6,228,396 Colonic drug delivery composition 10 1997
 
ASCENT PEDIATRICS, INC. (1)
5,672,358 Controlled release aqueous emulsion 10 1995
 
BAR-ILAN UNIVERSITY (1)
8,093,211 Methods and pharmaceutical compositions for healing wounds 0 2009
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
6,627,603 Method for releasing an active principle contained a multiple emulsion 9 1999
 
COGNIS DEUTSCHLAND GMBH & CO. KG (1)
5,817,254 Free-flowing emulsion concentrate 6 1996
 
DEXCEL LTD. (1)
7,732,404 Pro-nanodispersion for the delivery of cyclosporin 0 2006
 
FIRMENICH SA (1)
6,582,682 Oral care compositions comprising stabilized chlorine dioxide 14 2002
 
GS DEVELOPMENT AB (1)
6,660,278 Controlled release composition 13 1999
 
HAHNTECH INTERNATIONAL LIMITED (1)
6,582,749 Low fat edible emulsions 2 2001
 
Heal0r, Ltd. (1)
8,349,793 Method for treatment of inflammatory disease and disorder 0 2011
 
HEWLETT-PACKARD COMPANY (1)
6,024,786 Stable compositions of nano-particulate unmodified pigments and insoluble colorants in aqueous microemulsions, and principle of stability and methods of formation thereof 31 1997
 
HOFFMANN-LA ROCHE INC. (1)
6,008,228 Pharmaceutical compositions containing proteinase inhibitors 11 1996
 
INSTITUT FRANCAIS DU PETROLE (1)
7,605,123 Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof 3 2005
 
KAO CORPORATION (1)
5,693,258 Method for improving foaming properties and foaming composition 20 1994
 
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6,506,391 Cosmetic or dermatological composition in the form of a dispersion of an oily phase and an aqueous phase, stabilized with cubic gel particles 24 1999
 
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5,766,636 Edible, low calorie compositions of a carrier and an active ingredient and methods for preparation thereof 5 1995
 
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5,814,321 Oil adjuvant vaccine and method for preparing same 8 1996
 
PLIVA, INC. (1)
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PROTEIN DELIVERY INC. (1)
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SANWA KAGAKU KENKYUSHO CO., LTD. (1)
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SEMBIOSYS GENETICS INC. (1)
7,585,645 Thioredoxin and thioredoxin reductase containing oil body based products 0 2001
 
Societe d'Exploitation de Produits Pour les Industries Chemiques (SEPPIC) (1)
6,342,234 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 3 1997
 
SUMITOMO DAINIPPON PHARMA CO., LTD. (1)
8,178,102 Emulsified composition for dilution and cancer vaccine composition 0 2006
 
UNIVERSITY OF UTAH (1)
5,726,154 Stabilization and oral delivery of calcitonin 8 1996