US Patent No: 5,444,041

Number of patents in Portfolio can not be more than 2000

Convertible microemulsion formulations

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Abstract

There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ATHENA NEUROSCIENCES, INC.SOUTH SAN FRANCISCO, CA55

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Owen, Albert J West Chester, PA 6 159
Sarkahian, Ani B Bryn Mawr, PA 2 107
Yiv, Seang H Wilmington, DE 8 274

Cited Art

Patent Info (Count) # Cites Year
 
PFIZER INC. (2)
4,395,394 Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants 12 1981
4,806,350 Vaccine formulation 44 1986
 
RIBI IMMUNOCHEM RESEARCH, INC. (2)
4,803,070 Immunological emulsion adjuvants for polysaccharide vaccines 37 1986
4,806,352 Immunological lipid emulsion adjuvant 38 1986
 
Richardson-Vicks Inc. (2)
4,781,914 Sunscreen and moisturizer 18 1985
4,720,353 Stable pharmaceutical w/o emulsion composition 60 1987
 
Rorer Pharmaceutical Corporation (2)
5,026,825 Intranasal calcitonin formulations 15 1988
5,002,771 Calcitonin suppository formulations 21 1989
 
AAIPHARMA SERVICES CORP. (1)
5,206,219 Oral compositions of proteinaceous medicaments 127 1991
 
American Cyanamid Company (1)
4,650,677 Method of preparing adjuvanted live attenuated vaccines and adjuvanted live attenuated vaccines thus obtained 9 1984
 
ATHENA NEUROSCIENCES, INC. (1)
5,110,606 Non-aqueous microemulsions for drug delivery 28 1990
 
Bayer Aktiengesellschaft (1)
4,711,902 Medicament formulation 35 1984
 
CHESEBROUGH-POND'S INC. (1)
4,690,774 Novel translucent water in oil emulsions 19 1985
 
Chesebrough-Pond's USA Co., Division of Conopco, Inc. (1)
4,980,084 Water rinsable petroleum jelly compositions 10 1988
 
Exxon Research and Engineering Company (1)
4,183,918 Detoxifying-medicinal emulsions 13 1978
 
FD MANAGEMENT, INC. (1)
4,797,273 Skin moisturizing microemulsions 46 1986
 
FERRIS PHARMACEUTICALS INC. (1)
5,064,653 Hydrophilic foam compositions 52 1988
 
GIST-BROCADES N.V. (1)
4,481,188 Vaccines 13 1982
 
KAO CORPORATION (1)
5,036,108 Water-in-oil emulsion cosmetic 27 1989
 
KOREA FOOD RESEARCH INSTITUTE (1)
5,084,289 Method for the inhibition of oxidation of edible oils utilizing a fat soluble anti-oxidant and a water soluble anti-oxdant in a reverse micelle system 22 1990
 
MEDAPHORE (1)
4,914,084 Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body 20 1987
 
MEIJI MILK PRODUCTS CO., LTD. (1)
4,931,210 Process for producing a W/O/W type multiple emulsion for medicines, cosmetics, etc. 18 1988
 
MULLER, BERND W. (1)
4,719,239 Pharmaceutical multicomponent systems and method of preparing same 99 1985
 
NC Development, Inc. (1)
5,037,653 Pesticidal chemical formulations 40 1989
 
SMUCKER FRUIT PROCESSING COMPANY (1)
5,045,337 Food microemulsion 34 1990
 
Societe Nationale Elf Aquitaine (1)
4,460,692 Microemulsion of nutrient substances 14 1983
 
SYNTHETIC BLOOD CORPORATION (1)
4,963,367 Drug delivery compositions and methods 221 1987
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4,692,433 Method and composition for regulating serum calcium levels of mammals 86 1985
 
TROPONWERKE GMBH & CO. KG, A CORP. OF GERMANY (1)
4,731,384 Etofenamate formulation 16 1986
 
UNIVERSITY OF VIRGINIA (1)
5,036,045 Method for increasing growth hormone secretion 15 1988
 
Other [Check patent profile for assignment information] (1)
4,241,051 Calcitonin 14 1978

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
BIOCON LIMITED (25)
6,191,105 Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin 48 1997
6,858,580 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 21 2001
6,835,802 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 8 2001
6,828,297 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 9 2001
6,828,305 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2001
6,713,452 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 11 2001
6,913,903 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 4 2001
7,060,675 Methods of treating diabetes mellitus 6 2002
6,867,183 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 9 2002
7,713,932 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7,608,584 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7,196,059 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 3 2003
7,166,571 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 2 2003
7,312,192 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 0 2003
7,601,688 Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus 1 2003
7,030,084 Drug-oligomer conjugates with polyethylene glycol components 9 2004
7,084,121 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2004
7,084,114 Mixtures of insulin drug-oligomer comprising polyalkylene glycol 7 2004
7,611,864 Proinsulin polypeptide-oligomer conjugates 0 2004
7,875,700 Cation complexes of insulin compound conjugates, formulation and uses thereof 0 2005
7,872,095 Insulin-oligomer conjugates, formulations and uses thereof 0 2005
7,423,014 Insulin conjugates for treating diabetes mellitus 0 2005
7,470,663 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2006
7,381,702 Methods of treating diabetes mellitus 0 2006
8,030,269 Calcitonin drug-oligomer conjugates, and uses thereof 0 2009
 
ATHENA NEUROSCIENCES, INC. (5)
5,646,109 Convertible microemulsion formulations 22 1995
5,633,226 Convertible microemulsion formulations 25 1995
5,688,761 Convertible microemulsion formulations 21 1995
6,245,349 Drug delivery compositions suitable for intravenous injection 24 1996
6,241,969 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery 127 1998
 
WATSON LABORATORIES, INC. (5)
5,858,401 Pharmaceutical composition for cyclosporines 42 1997
7,070,802 Pharmaceutical compositions for lipophilic drugs 3 2001
7,988,995 Pharmaceutical compositions for lipophilic drugs 0 2002
8,119,157 Pharmaceutical compositions for lipophilic drugs 0 2006
7,799,340 Pharmaceutical compositions for lipophilic drugs 0 2007
 
LIPOCINE INC. (4)
6,267,985 Clear oil-containing pharmaceutical compositions 109 1999
6,309,663 Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents 79 1999
6,458,383 Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin 26 2000
6,761,903 Clear oil-containing pharmaceutical compositions containing a therapeutic agent 15 2001
 
MERRION RESEARCH III LIMITED (4)
8,119,159 Solid oral dosage form containing an enhancer 1 2006
8,323,689 Solid oral dosage form containing an enhancer 0 2008
8,053,429 Solid oral dosage form containing an enhancer 3 2009
8,323,690 Solid oral dosage form containing an enhancer 0 2010
 
SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (4)
6,274,149 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 3 1995
6,117,432 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 4 1997
6,251,407 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 4 1997
6,689,370 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 0 2000
 
ABBOTT LABORATORIES (3)
7,291,501 Stable compositions for measuring human natriuretic peptides 1 2003
7,351,586 Method of making stable calibrators or controls for measuring human natriuretic peptides 4 2005
7,674,623 Method of stabilizing human natriuretic peptides 0 2007
 
ENCINAL PHARMACEUTICAL INVESTMENTS, LLC (3)
6,174,547 Dosage form comprising liquid formulation 19 1999
7,147,867 Dosage form comprising liquid formulation 0 2000
7,803,401 Dosage form comprising liquid formulation 0 2006
 
CIMA LABS INC. (2)
6,280,770 Microemulsions as solid dosage forms for oral administration 20 1999
6,692,771 Emulsions as solid dosage forms for oral administration 13 2001
 
HEALOR LTD. (2)
7,638,484 Methods for accelerating wound healing by administration of adipokines 2 2006
8,367,606 Method and compositions for prevention and treatment of diabetic and aged skin 0 2006
 
NOF CORPORATION (2)
5,814,321 Oil adjuvant vaccine and method for preparing same 7 1996
8,178,102 Emulsified composition for dilution and cancer vaccine composition 0 2006
 
VESIFACT AG (2)
7,081,253 Use of nanodispersions in pharmaceutical end formulations 0 1999
7,871,642 Use of nanodispersions in pharmaceutical end formulations 0 2006
 
AJINOMOTO CO., INC. (1)
5,854,199 Cleaning compositions containing acylated dipeptides and acylated amino acids 2 1997
 
ARCHIMEDES DEVELOPMENT LIMITED (1)
6,228,396 Colonic drug delivery composition 9 1997
 
ASCENT PEDIATRICS, INC. (1)
5,672,358 Controlled release aqueous emulsion 10 1995
 
BAR-ILAN UNIVERSITY (1)
8,093,211 Methods and pharmaceutical compositions for healing wounds 0 2009
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
6,627,603 Method for releasing an active principle contained a multiple emulsion 2 1999
 
COGNIS DEUTSCHLAND GMBH & CO. KG (1)
5,817,254 Free-flowing emulsion concentrate 6 1996
 
COLUMBIA LABORATORIES, INC. (1)
7,153,845 Bioadhesive progressive hydration tablets 8 2003
 
DEXCEL LTD. (1)
7,732,404 Pro-nanodispersion for the delivery of cyclosporin 0 2006
 
FIRMENICH SA (1)
6,582,682 Oral care compositions comprising stabilized chlorine dioxide 5 2002
 
GS DEVELOPMENT AB (1)
6,660,278 Controlled release composition 11 1999
 
HAHNTECH INTERNATIONAL LIMITED (1)
6,582,749 Low fat edible emulsions 2 2001
 
Heal0r, Ltd. (1)
8,349,793 Method for treatment of inflammatory disease and disorder 0 2011
 
HEWLETT-PACKARD COMPANY (1)
6,024,786 Stable compositions of nano-particulate unmodified pigments and insoluble colorants in aqueous microemulsions, and principle of stability and methods of formation thereof 29 1997
 
HOFFMANN-LA ROCHE INC. (1)
6,008,228 Pharmaceutical compositions containing proteinase inhibitors 11 1996
 
INSTITUT FRANCAIS DU PETROLE (1)
7,605,123 Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof 1 2005
 
KAO CORPORATION (1)
5,693,258 Method for improving foaming properties and foaming composition 5 1994
 
L'OREAL (1)
6,506,391 Cosmetic or dermatological composition in the form of a dispersion of an oily phase and an aqueous phase, stabilized with cubic gel particles 22 1999
 
NATURA, INC. (1)
5,766,636 Edible, low calorie compositions of a carrier and an active ingredient and methods for preparation thereof 4 1995
 
PLIVA, INC. (1)
7,452,552 Pharmaceutical compositions for lipophilic drugs 0 2007
 
PROTEIN DELIVERY INC. (1)
7,169,889 Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin 1 2000
 
SANWA KAGAKU KENKYUSHO CO., LTD. (1)
5,733,877 Pharmaceutical composition containing biologically active peptide or protein 8 1995
 
SEMBIOSYS GENETICS INC. (1)
7,585,645 Thioredoxin and thioredoxin reductase containing oil body based products 0 2001
 
Societe d'Exploitation de Produits Pour les Industries Chemiques (SEPPIC) (1)
6,342,234 Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence 3 1997
 
UNIVERSITY OF UTAH (1)
5,726,154 Stabilization and oral delivery of calcitonin 7 1996
 
Other [Check patent profile for assignment information] (1)
8,466,134 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery 0 1999