TGF-.beta. induced gene
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United States of America Patent
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Aug 22, 1995
Issued Date -
N/A
app pub date -
May 4, 1992
filing date -
Feb 5, 1992
priority date (Note) -
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Abstract
A new TGF-.beta. induced gene and protein is described. Treatment of TGF-.beta. growth arrested cells induces the production of a novel gene which encodes a 683 amino acid protein, designated BIG-H3, that contains four homologous repeat regions and which may represent a cell surface recognition molecule. This gene and protein is induced in mammalian cells, and specifically human cells, upon treatment with TGF-.beta., and is shown to inhibit the growth of tumor cells.
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