Method for screening anti-osteoporosis agents
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United States of America Patent
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Aug 29, 1995
Grant Date -
N/A
app pub date -
Jun 21, 1993
filing date -
Jun 21, 1993
priority date (Note) -
Expired
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Abstract
The present invention relates to methods for the identification of therapeutic agents for the treatment of osteoporosis and serum lipid lowering agents. The invention relates to isolating cloning, and using nucleic acids from the promoter regions of transforming growth factor .beta. genes comprising novel regulatory elements designated 'raloxifene responsive elements'. The invention also encompasses eukaryotic cells containing such raloxifene responsive elements operably linked to reporter genes such that the raloxifene responsive elements modulate the transcription of the reporter genes. The invention provides methods for identifying anti-osteoporosis agents that induce transcription of genes operably linked to such raloxifene responsive elements without inducing deleterious or undesirable side effects associated with current anti-osteoporosis therapy regimens.
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