Amplification of the VB.sub.12 uptake system using polymers
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United States of America Patent
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Sep 12, 1995
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N/A
app pub date -
May 24, 1993
filing date -
May 24, 1993
priority date (Note) -
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Abstract
The invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B.sub.12 (VB.sub.12) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula: (V--Q).sub.n --P--(Q'--A).sub.m where, V is a carrier which will bind to natural intrinsic factor (IF) selected from vitamin B.sub.12 or an analogue thereof, n is the molar substitution ratio of V in the complex, and is a number from 1.0 to about 10, P is a pharmaceutically acceptable polymer, A is a pharmaceutically active substance, m is the molar substitution ratio of A in the complex, and is a number greater than 1.0 to about 1000, Q and Q' are independently a covalent bond, or a spacer compound linking V, P and A by covalent bonds.
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