X-ray contrast compositions useful in medical imaging

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United States of America Patent

PATENT NO 5451393
SERIAL NO

08207533

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Abstract

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An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, and a pharmaceutically acceptable carrier therefor is useful in x-ray diagnostic medical imaging methods. The agents can be delivered to a specific tissue or fluid site, for example, the blood pool, liver or spleen. In one embodiment involving intravenous administration, preferred compositions provide effective imaging of the blood pool for remarkably long times.

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Patent Owner(s)

Patent OwnerAddress
ALKERMES PHARMA IRELAND LIMITEDDUBLIN 4 D04 C5Y6

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cooper, Eugene R Berwyn, PA 78 3425
Liversidge, Gary G West Chester, PA 44 3454
McIntire, Gregory L West Chester, PA 47 1262
Shaw, J Michael King of Prussia, PA 2 162

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