US Patent No: 5,451,410

Number of patents in Portfolio can not be more than 2000

Modified amino acids for encapsulating active agents

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Abstract

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Modified amino acids and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The modified amino acids are preparable by reacting single amino acids or mixtures of two or more kinds of amino acids with an amino modifying agent such as benzene sulfonyl chloride, benzoyl chloride, and hippuryl chloride. The modified amino acids form encapsulating microspheres in the presence of the active agent under sphere-forming conditions. Alternatively, the modified amino acids may be used as a carrier by simply mixing the amino acids with the active agent. The modified amino acids are particularly useful in delivering peptides, e.g. insulin or calmodulin, or other agents which are sensitive to the denaturing conditions of the gastrointestinal tract.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EMISPHERE TECHNOLOGIES, INC.TARRYTOWN, NY150

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barantsetvich, Evgueni N New Rochelle, NY 1 111
Milstein, Sam J Larchmont, NY 59 2341

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
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Emisphere Technologies, Inc. (5)
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Japan Atomic Energy Research Institute (1)
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Ceskoslovenska akademie ved (1)
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NISSHIN OIL MILLS, LTD., THE (1)
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Dainippon Pharmaceutical Co., Ltd. (1)
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Biomaterials Universe Incorporated (1)
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BOEHRINGER BIOCHEMIA ROBIN S.P.A. (1)
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THE OHIO STATE UNIVERSITY (1)
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MITSUI TOATSU CHEMICALS, INC. (1)
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TOYO JOZO KABUSHIKI KAISHA (1)
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Kyoto Yakuhin Kogyo Kabushiki Kaisha (1)
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SANOFI, A FRENCH CORP. (1)
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PTLNV, LLC, SERIES ONE (1)
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MORELLE, JEAN V. (1)
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Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
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9,511,198 Dry powder inhaler and system for drug delivery 0 2013
 
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5,650,386 Compositions for oral delivery of active agents 118 1995
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5,866,536 Compounds and compositions for delivering active agents 82 1997
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6,428,780 Compounds and compositions for delivering active agents 22 1999
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9,370,492 Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers 0 2009
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ALNIS BIOSCIENCES, INC. (1)
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Mankind Corporation (1)
9,192,675 Dry powder inhaler and system for drug delivery 0 2013
 
IRONWOOD PHARMACEUTICALS, INC. (2)
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7,384,982 Disodium salts, monohydrates, and ethanol solvates for delivering active agents 4 2003
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* 2008/0269,134 DISODIUM SALTS, MONOHYDRATES, AND ETHANOL SOLVATES FOR DELIVERING ACTIVE AGENTS 0 2008
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Ironwwod Pharmaceuticals, Inc. (1)
8,933,030 Treatments for gastrointestinal disorders 0 2011
 
MHR Institutional Partners IIA LP (3)
* 2005/0042,274 Compounds and compositions for delivering active agents 0 2003
* 2005/0255,138 Active agent transport systems 0 2005
7,417,022 Compounds and compositions for delivering active agents 1 2005
 
VIRGINIA COMMONWEALTH UNIVERSITY (3)
6,627,228 Polymeric delivery agents and delivery agents compounds 34 2001
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* 2007/0141,022 POLYMERIC DELIVERY AGENTS AND DELIVERY AGENT COMPOUNDS 1 2007
 
D-DUE DIVISIONE LASER S.R.L. (2)
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NEC CORPORATION (1)
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MANNKIND CORPORATION (16)
5,976,569 Diketopiperazine-based delivery systems 102 1997
6,395,774 Carbon-substituted diketopiperazine delivery systems 69 2001
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9,339,615 Dry powder inhaler and system for drug delivery 0 2013
9,241,903 Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent 0 2013
9,283,193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 0 2014
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9,446,133 Dry powder inhaler and system for drug delivery 0 2014
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TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (1)
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* Cited By Examiner