Modified amino acids for encapsulating active agents

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5451410
SERIAL NO

08051019

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Modified amino acids and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The modified amino acids are preparable by reacting single amino acids or mixtures of two or more kinds of amino acids with an amino modifying agent such as benzene sulfonyl chloride, benzoyl chloride, and hippuryl chloride. The modified amino acids form encapsulating microspheres in the presence of the active agent under sphere-forming conditions. Alternatively, the modified amino acids may be used as a carrier by simply mixing the amino acids with the active agent. The modified amino acids are particularly useful in delivering peptides, e.g. insulin or calmodulin, or other agents which are sensitive to the denaturing conditions of the gastrointestinal tract.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EMISPHERE TECHNOLOGIES, INC.TARRYTOWN, NY150

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barantsetvich, Evgueni N New Rochelle, NY 1 113
Milstein, Sam J Larchmont, NY 59 2426

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
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EMISPHERE TECHNOLOGIES, INC. (5)
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Ceskoslovenska akademie ved (1)
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THE OHIO STATE UNIVERSITY (1)
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PTLNV, LLC, SERIES ONE (1)
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MORELLE, JEAN V. (1)
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
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Other [Check patent profile for assignment information] (1)
* 2009/0286,735 METHOD FOR ADMINISTERING GLP-1 MOLECULES 2 2009
 
ALNIS BIOSCIENCES, INC. (1)
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Ironwwod Pharmaceuticals, Inc. (1)
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MHR Institutional Partners IIA LP (3)
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VIRGINIA COMMONWEALTH UNIVERSITY (3)
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D-DUE DIVISIONE LASER S.R.L. (2)
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* Cited By Examiner