Human relaxin formulation
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United States of America Patent
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Sep 19, 1995
Issued Date -
N/A
app pub date -
Apr 20, 1993
filing date -
Feb 26, 1988
priority date (Note) -
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Abstract
A pharmaceutical composition is provided wherein human relaxin is formulated at an acidic pH of about 4 to less than about 7. The composition, useful for effecting parturition and inhibiting premature delivery, includes a buffer capable of maintaining the pH of the composition within a desired range, and may also include an agent to make the composition isotonic, and a stabilizing agent, if necessary. A specific example is human relaxin formulated in a citrate buffer, pH about 5.0, in the presence of sodium chloride, at an ionic strength of about 0.15 .mu..
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