Process for the activation of t-PA or Ing after genetic expression in prokaryotes

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United States of America Patent

PATENT NO 5453363
SERIAL NO

08206044

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Abstract

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A process for the activation of t-PA or IgG after expression in prokaryotes is described. The process includes cell digestion, solubilization under denaturing and reducing conditions and activation under oxidizing conditions in the presence of GSH/GSSG.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER MANNHEIM GMBHTHE FEDERAL REPUBLIC OF GERMANY MANNHEIM MANNHEIM BADEN-WURTTEMBERG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fischer, Stephan Weilheim, DE 99 763
Mattes, Ralf Oberhausen, DE 27 334
Rudolph, Rainer Regensburg, DE 34 406

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