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Abstract

An aerosol-dispensable pharmaceutical composition consisting essentially of a combination of lidocaine free base, a pharmacologically-acceptable phenylephrine acid addition salt, and a pharmacologically-acceptable organic solvent, all dissolved in a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane of the formula CF.sub.3 CH.sub.2 F (HFC-134a) and 1,1,1,2,3,3,3-heptafluoropropane of the formula CF.sub.3 CHFCF.sub.3 (HFC-227) or a combination of the said propellants, suitable for dispensing by means of a metered-dosage valve canister in which it is contained under pressure, avoids the necessity of premixing individual solutions by the physician just prior to use. The phenylephrine salt is preferably the hydrochloride and the solvent is preferably ethanol although other pharmacologically-acceptable solvents and pharmacologically-acceptable acid addition salts of phenylephrine may be employed. The lidocaine free base assists in solubilizing the phenylephrine salt and maintaining it in solution in the propellant.

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