Terfenadine oral powder
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United States of America Patent
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Oct 3, 1995
Grant Date -
N/A
app pub date -
Jan 4, 1995
filing date -
Jan 4, 1995
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention contemplates a dry, powdered terfenadine composition. That composition comprises (a) a mixture of: (i) about 1 to about 20 parts by weight micronized terfenadine and (ii) about 0.2 to about 10 parts by weight a polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymer having an HLB number of 24 that is a wetting agent for said terfenadine; that are dry-blendedly dispersed into: (b) about 20 to about 40 parts by weight spray-dried sorbitol particles that are loosely packed, randomly oriented filamentary crystals having pores that entrap said terfenadine particles and wetting agent upon said dry-blended dispersal, said components being further dry blended with (c) about 2 to about 10 parts by weight dry polyvinylpyrrolidone; (d) about 1 to about 5 parts by weight of a dry mixture of microcrystalline cellulose and sodium carboxymethylcellulose; and (e) a dry flavorant in an amount sufficient to provide a desired taste to said powder; said composition being a free-flowing powder that is substantially free from the taste of terfenadine when placed on the human tongue in dry form or when dispersed in water and tasted within about five minutes of said dispersal.
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