US Patent No: 5,455,166

Number of patents in Portfolio can not be more than 2000

Strand displacement amplification

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Abstract

This invention relates a nucleic acid target amplification and detection method which operates at a single temperature and makes use of a polymerase in conjunction with an endonuclease that will nick the polymerized strand such that the polymerase will displace the strand without digestion while generating a newly polymerized strand.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BECTON, DICKINSON AND COMPANYFRANKLIN LAKES, NJ2398

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Walker, George T Chapel Hill, NC 20 577

Cited Art

Patent Info (Count) # Cites Year
 
ROCHE MOLECULAR SYSTEMS, INC. (2)
4,683,202 Process for amplifying nucleic acid sequences 2764 1985
4,683,195 Process for amplifying, detecting, and/or-cloning nucleic acid sequences 2436 1986
 
BECTON, DICKINSON AND COMPANY (1)
5,270,184 Nucleic acid target generation 128 1991

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
BECTON, DICKINSON AND COMPANY (20)
5,800,989 Method for detection of nucleic acid targets by amplification and fluorescence polarization 17 1995
5,641,633 Fluorescence polarization detection of nucleic acids 30 1995
5,702,926 Nicking of DNA using boronated nucleotides 4 1996
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5,863,736 Method, apparatus and computer program products for determining quantities of nucleic acid sequences in samples 31 1997
5,935,791 Detection of nucleic acids by fluorescence quenching 25 1997
6,066,458 Methods, apparatus and computer program products for determining quantities of nucleic acid sequences in samples using standard curves and amplification ratio estimates 14 1998
6,130,047 Detection of nucleic acids by fluorescence quenching 6 1999
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6,316,200 Probes and methods for detection of nucleic acids 20 2000
6,261,784 Detection of nucleic acids by strand displacement 3 2000
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APPLIED BIOSYSTEMS, LLC (7)
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6,870,045 Kits for detecting HIV-2 0 2001
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NANOGEN/BECTON DICKINSON PARTNERSHIP (5)
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UNIVERSITY OF UTAH (5)
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