Process for transforming a human insulin precursor to human insulin
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United States of America Patent
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Oct 10, 1995
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app pub date -
May 11, 1992
filing date -
Oct 14, 1986
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Abstract
This specification describes a process for converting a human insulin precursor to human insulin, which comprises treating such human insulin precursor with trypsin and carboxypeptidase B in an aqueous medium containing per mole of human insulin precursor from about 0.1 to about 10 moles of one or more metal ions of those metals having Atomic Numbers 21 to 34, 39 to 52, 57 to 84, and 89 to 92.
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