US Patent No: 5,457,110

Number of patents in Portfolio can not be more than 2000

Apioid analgesic without respiratory depression

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A biologically active preparation for human or veterinary use for the selective blockade of opioid binding sites of the brain responsible for respiratory depression containing in a biologically active quantity the codeinone derivative of general formula (I) or its salt R.sup.1 means amino-, hydroxyl-, --NH-phenyl or --NH--CO--NH.sub.2 groups, R.sup.2 means a hydrogen atom or a hydroxyl group. The invention also covers a process for selective blocking the opioid binding sites of the brain responsible for respiratory depression by administering to a patient in need of an analgetic a preparation containing a codeinone derivative of general formula (I) or its salt preferably three times per day in doses of 2.5-5 mg. A preferred feature of the inventions is an analgetic composition containing a codeinone derivative of general formula (I) and in a mass ratio of 1:2-3 morphine of the formula (IV) or an other, biologically equipotent agonist type opiate or opioid compound and optionally inert, pharmaceutically acceptable accompanying materials.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ICN HUNGARY RT.KABAY, HU3

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benyhe, Sandor Szeged Josef A. sugarut, HU 2 52
Borsodi, Anna Szeged Vitez utca, HU 2 52
Buzas, Beata Eger Maklari, HU 1 1
Friedmann, Tamas Budapest Budekeszi, HU 2 52
Furst, Zsuzsa Budapest Toldy, HU 3 70
Hosztafi, Sandor Monostorpaly Arpad, HU 4 55
Szucs, Maria Szeged Josef A. sugarut, HU 2 52
Varga, Schafferne E Szeged Fofasor, HU 2 52

Cited Art Landscape

Patent Info (Count) # Cites Year
 
NOVA PHARMACEUTICAL CORPORATION (2)
4,760,069 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 57 1985
4,889,860 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 61 1987
 
Alkaloida Vegyeszeti Gyar (1)
5,232,926 Morphinane-skeletoned hydrazone derivatives 1 1992

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
QRXPHARMA LTD. (1)
8,182,837 Methods and compositions for reducing the risk associated with the administration of opioid analgesics in patients with diagnosed or undiagnosed respiratory illness 0 2006