Pharmaceutical compositions of indazoles and methods of use thereof
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United States of America Patent
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Oct 17, 1995
Grant Date -
N/A
app pub date -
Dec 17, 1993
filing date -
Dec 18, 1992
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Indazoles of Formula (I) ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each separately selected from hydrogen, halogeno, halogenoalkyl, formyl, carboxy, sulpho, cyano, nitro, COR and .sup.+ NRR'R' groups, wherein R, R' and R' are each separately alkyl, aralkyl or aryl groups, and R.sub.5 is selected from hydrogen, halogeno, halogenoalky, formyl, carboxy, sulpho, cyano, nitro, hydroxy, alkoxy, alkyl, COR, NHCOR and .sup.+ NRR'R' groups, wherein R, R' and R' are each separately alkyl, aralkyl or aryl groups, which may optionally be in the form of a physiologically acceptable ester or salt, are of value for use as an analgesic or in the treatment of any condition where the inhibition of brain/spinal cord nitric oxide synthase is advantageous, for example in neurodegenerative disease.
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