Peptides which serve as substrates for a phosphokinase and methods for their use to modify antibodies in order to facilitate radioabelling of antibodies with .sup.32 P
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United States of America Patent
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Oct 17, 1995
Issued Date -
N/A
app pub date -
Oct 7, 1994
filing date -
Jan 21, 1986
priority date (Note) -
Expired
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Abstract
A method is provided for attaching .sup.32 P to a protein, normally an antibody, that will bind with and irradiate a tumor-associated structure leading to diagnostic benefit. The invention is based upon the introduction of a peptide region to the protein, which is capable of acting as a substrate for a phosphokinase utilizing .sup.32 P-.gamma.-ATP as a typical source of the radionuclide. The conjugation of the substrate molecule to the protein may be achieved by chemical methods or by genetic engineering techniques. Novel substrate peptides are disclosed.
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