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Abstract

An improved axial flow chromatography column for separations dependent upon bed depth, such as size exclusion and where changes of column volume necessitate bed height adjustments. The improvements include a snap-action lever or a collet arrangement which permits quick and easy movement of the bed adjuster; a flush seal assembly at the outlet frit and a V-shaped seal in the bed adjuster which obviates dead volume gap of conventional O-ring seals; lens-shaped frits convex on the inlet and outlet sides provide for uniform flow through the column, and the access ports eliminate the contamination problem by providing easy access for cleaning and aspiration of liquid; and a combined inlet tube and adjuster tube assembly eliminates the need for threaded components which make sanitation difficult.

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First Claim