Semipermeable microspheres encapsulating biological material
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United States of America Patent
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Oct 31, 1995
Issued Date -
N/A
app pub date -
Sep 23, 1993
filing date -
Dec 23, 1991
priority date (Note) -
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Abstract
Microspheres of a substantially uniform diameter are produced having a central portion composed of a solution of a polyanion containing a biological material, and an outer permeable membrane enclosing the central portion which is a complex of the polyanion and a polycation. The biological material has a molecular size greater than 150,000 Daltons, and the membrane has a porosity such that the biological material does not permeate the membrane. The biological material may comprise living cells or living tissue. The microspheres are formed by individually enveloping falling droplets of a polyanion solution with a collapsing annular sheet of a polycation solution while the sheet is traveling downwardly at the same velocity as the droplets.
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